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Brain O2 reserve in sickle cell disease
| Content Provider | Scilit |
|---|---|
| Author | Wood, John C. |
| Copyright Year | 2019 |
| Description | In this issue of Blood, Fields and colleagues demonstrate that patients with sickle cell disease (SCD) on hydroxyurea have lower cerebral oxygen extraction fraction (OEF) than similar patients not receiving disease-modifying $therapy.^{1}$ Although hydroxyurea has become the standard of care for young children with SCD, its ability to protect the white matter from silent strokes remains unknown. In the Créteil cohort, SCD patients had access to regular TCD screening since birth, and hydroxyurea was routinely administered to children with frequent vasoocclusive crises. Despite this, the prevalence of silent strokes was 37.4% by the age of 14 in this $cohort.^{2}$ With the increasing use of hydroxyurea, in lieu of transfusion therapy, for SCD patients with abnormal transcranial Doppler $results,^{3}$ there is appropriate anxiety about hydroxyurea’s cerebral protection. |
| Related Links | https://ashpublications.org/blood/article-pdf/133/22/2356/1553465/blood901124.pdf |
| Ending Page | 2358 |
| Page Count | 3 |
| Starting Page | 2356 |
| DOI | 10.1182/blood-2019-04-901124 |
| Journal | Blood |
| Issue Number | 22 |
| Volume Number | 133 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2019-05-30 |
| Access Restriction | Open |
| Subject Keyword | Hematology Children Hydroxyurea Scd Sickle Cell Cerebral Cell Disease Silent Strokes Journal: Blood (Vol- 136, Issue- 22) |
| Content Type | Text |
| Resource Type | Article |
