NDLI: How I treat renal complications in sickle cell disease

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How I treat renal complications in sickle cell disease

Content Provider	Scilit
Author	Sharpe, Claire C. Thein, Swee Lay
Copyright Year	2014
Description	Renal disease is one of the most frequent and severe complications experienced by patients with sickle cell disease; its prevalence is likely to increase as the patient population ages. We recommend regular monitoring for early signs of renal involvement and a low threshold for the use of hydroxyurea as preventative measures for end-stage renal disease. Once renal complications are detected, a careful assessment of the patient is required to rule out other causes of renal disease. Proteinuria and hypertension should be managed aggressively and the patient referred to a specialist nephrology center when progressive decline in renal function is noted. For the few patients who develop advanced chronic kidney disease, timely planning for dialysis and transplantation can significantly improve outcome, and we recommend an exchange blood transfusion policy for all patients on the transplant waiting list and for those with a functioning graft. Alongside the invasive treatment regimes, it is important to remember that renal failure in conjunction with sickle cell disease does carry a significant burden of morbidity and that focusing on symptom control has to be central to good patient care.
Related Links	http://www.bloodjournal.org/content/bloodjournal/123/24/3720.full.pdf?sso-checked%3Dtrue
Ending Page	3726
Page Count	7
Starting Page	3720
DOI	10.1182/blood-2014-02-557439
Journal	Blood
Issue Number	24
Volume Number	123
Language	English
Publisher	American Society of Hematology
Publisher Date	2014-06-12
Access Restriction	Open
Subject Keyword	Hematology Sickle Cell Disease Hydroxyurea Chronic Kidney Disease Renal Complications Renal Failure Remember Renal Disease Blood Transfusion Journal: Blood (Vol- 138, Issue- 24)
Content Type	Text
Resource Type	Article

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