NDLI: T lymphocytes lack rearrangement of the bcr gene in Philadelphia chromosome-positive chronic myelocytic leukemia

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T lymphocytes lack rearrangement of the bcr gene in Philadelphia chromosome-positive chronic myelocytic leukemia

Content Provider	Scilit
Author	Bartram, Cr Raghavachar, A. Anger, B. Stain, C. Bettelheim, P.
Copyright Year	1987
Description	To study the possible involvement of T lymphocytes in Philadelphia chromosome (Ph)-positive chronic myelocytic leukemia (CML) we analyzed the arrangement of the bcr gene in T cell and non-T cell samples of 12 CML patients. Although all the patients showed bcr rearrangements in non-T cell fractions, T cell populations lacked respective gene recombinations. Moreover, by Southern blot analyses using T cell receptor beta chain sequences our data indicate polyclonality of T cell samples from 11 of 12 cases; in one patient a clonal T cell population could be identified. These results suggest that T lineages of most Ph- positive CML patients are not derived from pluripotent stem cells involved in leukemogenesis and thus confirm previous investigations based on cytogenetic or glucose-6-phosphate dehydrogenase analyses. The demonstration of polyclonal T cell populations may reflect persistence of stem cells committed to differentiate only into T cells.
Related Links	https://ashpublications.org/blood/article-pdf/69/6/1682/596316/1682.pdf
Ending Page	1685
Page Count	4
Starting Page	1682
DOI	10.1182/blood.v69.6.1682.1682
Journal	Blood
Issue Number	6
Volume Number	69
Language	English
Publisher	American Society of Hematology
Publisher Date	1987-06-01
Access Restriction	Open
Subject Keyword	Hematology Lymphocytes Leukemia Chromosome Polyclonal Bcr Cml Philadelphia Myelocytic Differentiate Cell Populations Journal: Blood (Vol- 87, Issue- 6)
Content Type	Text
Resource Type	Article

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