NDLI: BCR-ABL rearrangements in children with Philadelphia chromosome- positive chronic myelogenous leukemia

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BCR-ABL rearrangements in children with Philadelphia chromosome- positive chronic myelogenous leukemia

Content Provider	Scilit
Author	Aurer, I. Butturini, A. Gale, Rp
Copyright Year	1991
Description	Leukemia cells from adults with Philadelphia (Ph1)-chromosome positive chronic myelogenous leukemia (CML) have a characteristic molecular rearrangement between the BCR and ABL genes whereby major breakpoint cluster region (Mbcr) exons 2 or 3 are joined to ABL exon II. Ph1- chromosome positive CML is uncommon in children and it is unknown whether these children have similar rearrangements. We studied 17 children with Ph1-chromosome positive CML. Five were studied for Mbcr rearrangement using Southern blotting, nine for the presence of chimeric BCR-ABL mRNA using reverse transcription and polymerase chain reaction, and three for both. All eight children studied by Southern blotting had BCR rearrangement. Of 12 children in whom BCR-ABL mRNA was studied, 10 had Mbcr exon 2 joined to ABL exon II, one had Mbcr exon 3 joined to ABL II, and one had both Mbcr-ABL junctions. These data indicate a similarity to adult CML. However, mRNA processing in children may preferentially splice Mbcr exon 2 to ABL exon II. No child had BCR exon 1 joined to ABL exon II, the rearrangement typical of childhood Ph1-chromosome positive acute lymphoblastic leukemia.
Related Links	https://ashpublications.org/blood/article-pdf/78/9/2407/224581/2407.pdf
Ending Page	2410
Page Count	4
Starting Page	2407
DOI	10.1182/blood.v78.9.2407.bloodjournal7892407
Journal	Blood
Issue Number	9
Volume Number	78
Language	English
Publisher	American Society of Hematology
Publisher Date	1991-11-01
Access Restriction	Open
Subject Keyword	Hematology Children Adults Rearrangement Chromosome Cml Joined Mbcr Bcr Abl Abl Exon Journal: Blood (Vol- 107, Issue- 9)
Content Type	Text
Resource Type	Article

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