NDLI: bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia

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bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia

Content Provider	Scilit
Author	Klein, A. De Hagemeijer, A. Bartram, Cr Houwen, R. Hoefsloot, L. Carbonell, F. Chan, L. Barnett, M. Greaves, M. Kleihauer, E.
Copyright Year	1986
Description	The Philadelphia (Ph1) chromosome, the cytogenetic hallmark of chronic myeloid leukemia (CML), has also been detected in a significant number of acute lymphoblastic leukemias (ALL). Using in situ hybridization, we demonstrate that in accordance with observations in CML the Ph1 chromosome in ALL patients is the result of a consistent translocation of the c-abl oncogene to the Ph1 chromosome. Southern blot analysis using bcr probes, however, suggests that Ph1-positive ALL includes heterogeneous leukemic subtypes: six ALL patients showed bcr rearrangements as observed in CML; in three other patients recombination involving 5′ bcr sequences could be demonstrated, but the corresponding translocated 3′ bcr sequences were not detectable. A third group of five patients did not show any bcr rearrangements at all. Northern blot analysis using RNA from three Ph1-positive ALL patients revealed that in the leukemic cells of two patients larger c- abl mRNA transcripts were present, as in CML. In the RNA of one patient without a detectable bcr rearrangement, only the normal c-abl mRNA transcripts are present. The observed heterogeneity in bcr rearrangements of this group of Ph1-positive ALL patients is in contrast with the consistent results obtained in more than 50 Ph1- positive CML patients investigated in chronic and acute states.
Related Links	https://ashpublications.org/blood/article-pdf/68/6/1369/595365/1369.pdf
Ending Page	1375
Page Count	7
Starting Page	1369
DOI	10.1182/blood.v68.6.1369.1369
Journal	Blood
Issue Number	6
Volume Number	68
Language	English
Publisher	American Society of Hematology
Publisher Date	1986-12-01
Access Restriction	Open
Subject Keyword	Hematology Leukemia Cml Ph1 Philadelphia Lymphoblastic Leukemic Blot Bcr Rearrangements Journal: Blood (Vol- 87, Issue- 6)
Content Type	Text
Resource Type	Article

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