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Philadelphia chromosome positive childhood acute lymphoblastic leukemia
| Content Provider | Scilit |
|---|---|
| Author | Priest, Jr Robison, Ll McKenna, Rw Lindquist, Ll Warkentin, Pi LeBien, Tucker Woods, Wg Kersey, Jh Coccia, Pf Nesbit, Me Jr |
| Copyright Year | 1980 |
| Description | In a 3-yr period, the Philadelphia chromosome (Ph1) was found in 4 of 43 children with acute lymphoblastic leukemia (ALL) in whom chromosomes were studied at diagnosis. The clinical, morphological, cytochemical, and immunologic findings in the Ph1-positive (PH1+) CASES WERE CONsistent with typical childhood ALL, indicating that identification of cases requires chromosome studies. A review of all reported cases of Ph1 + childhood ALL shows that Ph1 + patients are older and have higher initial platelet and white blood cell counts (WBC) than most children with ALL. However, a life table comparison between the reported cases of Ph1 + ALL in children and randomly selected age-, sex-, and WBC- matched controls with ALL shows the duration of first marrow remission to be significantly shorter (p less than 0.02) for the Ph1 + cases Ph1 + ALL is a distinct subtype of childhood ALL that is not rare and can be identified only by cytogenetic studies. The prognosis is poor. Cytogenetic studies should be done prospectively in a large group of children with ALL to define further the subgroup of patients and to confirm the findings of this retrospective analysis. |
| Related Links | https://ashpublications.org/blood/article-pdf/56/1/15/583285/15.pdf |
| Ending Page | 22 |
| Page Count | 8 |
| Starting Page | 15 |
| DOI | 10.1182/blood.v56.1.15.15 |
| Journal | Blood |
| Issue Number | 1 |
| Volume Number | 56 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1980-07-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Pediatrics and Child Health Children Childhood Leukemia Chromosome Philadelphia Cytogenetic Wbc Lymphoblastic Cases of Ph1 Journal: Blood (Vol- 3, Issue- 1) |
| Content Type | Text |
| Resource Type | Article |
