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Philadelphia chromosome positive childhood acute lymphoblastic leukemia: clinical and cytogenetic characteristics and treatment outcome. A Pediatric Oncology Group study
| Content Provider | Scilit |
|---|---|
| Author | Crist, W. Carroll, A. Shuster, J. Jackson, J. Head, D. Borowitz, M. Behm, F. Link, M. Steuber, P. Ragab, A. |
| Copyright Year | 1990 |
| Description | Among 3,638 children with acute lymphoblastic leukemia (ALL) entered on Pediatric Oncology Group (POG) protocols between June 1981 and April 1989, successful cytogenetic studies were available for 2,519, 58 (2.3%) of which had the Philadelphia (Ph) chromosome detected. Features associated with the presence of the Ph chromosome were high leukocyte count (median, 33 x 10(9)/L), older age median, 9.6 years), a higher proportion of French-American-British L2 morphology, and a lower frequency of mediastinal mass. Immunologic marker studies at diagnosis in 56 Ph+ cases identified early pre-B ALL in 42 cases (75%), pre-B- cell in 9 (16%), and T-cell in 5 (9%). This distribution is similar to that found in Ph+ ALL. Intensive multiagent chemotherapy induced complete remissions in only 78% of eligible Ph+ patients compared with 96% of those without an identified Ph chromosome (P less than .001). Of 44 eligible Ph+ patients treated on POG frontline protocols for children with non-T, non-B-cell ALL, 27 have failed therapy, compared with 520 of 1,892 without an identified Ph chromosome (logrank P less than .001). Ph+ ALL is an aggressive form of acute leukemia that frequently presents in older children with a high leukocyte count, FAB L2 morphology, and a pseudodiploid karyotype, and becomes multidrug- resistant early. Thus, Ph+ cases require early identification to permit treatment with intensive induction regimens and experimental approaches such as bone marrow transplantation. |
| Related Links | https://ashpublications.org/blood/article-pdf/76/3/489/603627/489.pdf |
| Ending Page | 494 |
| Page Count | 6 |
| Starting Page | 489 |
| DOI | 10.1182/blood.v76.3.489.489 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 76 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1990-08-01 |
| Access Restriction | Open |
| Subject Keyword | Pediatrics and Child Health Children Treatment Bone Marrow Pediatric Oncology Chromosome Pre Cytogenetic Lymphoblastic Eligible Journal: Blood (Vol- 68, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |
