NDLI: Little evidence of donor-derived epithelial cells in early digestive acute graft-versus-host disease

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Little evidence of donor-derived epithelial cells in early digestive acute graft-versus-host disease

Content Provider	Scilit
Author	Meignin, Véronique Soulier, Jean Brau, Frédéric Lémann, Marc Gluckman, Eliane Janin, Anne Socié, Gérard
Copyright Year	2004
Description	Donor origin of epithelial intestinal cells has been studied in animals and humans after transplantation and has been used as evidence of hematopoietic stem cell (HSC) plasticity. However, in the human gastrointestinal tract, no study used X- or Y-chromosome detection by fluorescence in situ hybridization (FISH) coupled with immunologic stainings to characterize cell types on the same tissue section. Here, we combined these techniques on the same section of duodenal epithelium in 6 patients with acute graft-versus-host disease. Donor-derived lymphoid cells were detected in the epithelium and the lamina propria, as expected. However, using our stringent criteria, no donor-derived cells could be proven to be epithelial.
Related Links	http://www.bloodjournal.org/content/bloodjournal/103/1/360.full.pdf
Ending Page	362
Page Count	3
Starting Page	360
DOI	10.1182/blood-2003-06-1843
Journal	Blood
Issue Number	1
Volume Number	103
Language	English
Publisher	American Society of Hematology
Publisher Date	2004-01-01
Access Restriction	Open
Subject Keyword	Gastroenterology and Hepatology Donor Derived Acute Graft Hematopoietic Plasticity Epithelial Graft Versus Host Host Disease Journal: Blood (Vol- 14, Issue- 1)
Content Type	Text
Resource Type	Article

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