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Donor-derived interferon γ separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells
| Content Provider | Scilit |
|---|---|
| Author | Yang, Yong-Guang Qi, Jin Wang, Min-Guang Sykes, Megan |
| Copyright Year | 2002 |
| Description | The graft-versus-leukemia (GVL) effects and graft-versus-host disease (GVHD)–inducing activity of CD8 T cells was compared in murine recipients of wild-type (WT) or interferon γ (IFN-γ)–deficient (GKO) allogeneic donor cells. CD8 T cells (or CD4-depleted splenocytes) from GKO donor mice induced more severe GVHD in lethally irradiated allogeneic recipients compared to the same cell populations from WT donors. Consistent with GVHD severity, donor CD8 T-cell expansion in allogeneic recipients was augmented in the absence of IFN-γ. These results demonstrate that IFN-γ does not stimulate but instead down-modulates GVHD induced by donor CD8 T cells. Remarkably, antihost lymphohematopoietic reactions, including GVL effects against host leukemia/lymphoma cells, of CD8 T cells correlated inversely with their GVHD-inducing activity, and those of GKO donors were markedly weaker than those mediated by WT donor CD8 T cells. These data show for the first time that GVHD-inducing activity and GVL effects of allogeneic CD8 T cells can be separated by a single cytokine, IFN-γ. |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/99/11/4207.full.pdf |
| Ending Page | 4215 |
| Page Count | 9 |
| Starting Page | 4207 |
| DOI | 10.1182/blood.v99.11.4207 |
| Journal | Blood |
| Issue Number | 11 |
| Volume Number | 99 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2002-06-01 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Gvhd Inducing Activity Donor Cd8 T Cells Graft Leukemia Journal: Blood (Vol- 117, Issue- 11) |
| Content Type | Text |
| Resource Type | Article |
