NDLI: High molecular response rate of polycythemia vera patients treated with pegylated interferon -2a

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High molecular response rate of polycythemia vera patients treated with pegylated interferon -2a

Content Provider	Scilit
Author	Kiladjian, Jean-Jacques Cassinat, Bruno Turlure, Pascal Cambier, Nathalie Roussel, Murielle Bellucci, Sylvia Menot, Marie-Laurence Massonnet, Gerald Dutel, Jean-Luc Ghomari, Kamel Rousselot, Philippe Grange, Marie-Jose Chait, Yasmina Vainchenker, William Parquet, Nathalie Abdelkader-Aljassem, Lina Bernard, Jean-François Rain, Jean-Didier Chevret, Sylvie Chomienne, Christine Fenaux, Pierre
Copyright Year	2006
Description	V617F JAK2 mutation is a reliable molecular marker of polycythemia vera (PV), potentially useful to monitor the effect of treatments in this disease. In a phase 2 study of pegylated (peg) IFN-α–2a in PV, we performed prospective sequential quantitative evaluation of the percentage of mutated JAK2 allele (%V617F) by real-time polymerase chain reaction (PCR). The %V617F decreased in 24 (89%) of 27 treated patients, from a mean of 49% to a mean of 27% (mean decrease of 44%; P < .001), and no evidence for a plateau was observed. In one patient, mutant JAK2 was no longer detectable after 12 months. In 3 patients homozygous for the mutation, reappearance of 50% of wild-type allele was observed during treatment. The results seem to confirm the hypothesis that IFN-α preferentially targets the malignant clone in PV and show that %V617F assessment using a quantitative method may provide the first tool to monitor minimal residual disease in PV. This trial was registered at www.clinicaltrials.gov as #NCT00241241.
Related Links	http://www.bloodjournal.org/content/108/6/2037.full.pdf
Ending Page	2040
Page Count	4
Starting Page	2037
DOI	10.1182/blood-2006-03-009860
Journal	Blood
Issue Number	6
Volume Number	108
Language	English
Publisher	American Society of Hematology
Publisher Date	2006-09-15
Access Restriction	Open
Subject Keyword	Hematology Treatment Ifn Allele Jak2 Pegylated Polycythemia Vera V617f Journal: Blood (Vol- 90, Issue- 6)
Content Type	Text
Resource Type	Article

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