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High molecular response rate of polycythemia vera patients treated with pegylated interferon alpha-2a.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kiladjian, Jean-Jacques Cassinat, Bruno Turlure, Pascal Cambier, Nathalie Roussel, Murielle Bellucci, Sylvia Menot, Marie-Laurence Massonnet, Gérald Dutel, J. L. Ghomari, Kamel Rousselot, Philippe Grange, Marie-José Chait, Yasmina Vainchenker, William Parquet, Nathalie Abdelkader-Aljassem, Lina Bernard, J. Rain, J. D. Chevret, Sylvie Chomienne, Christine Fenaux, Pierre |
| Copyright Year | 2006 |
| Abstract | V617F JAK2 mutation is a reliable molecular marker of polycythemia vera (PV), potentially useful to monitor the effect of treatments in this disease. In a phase 2 study of pegylated (peg) IFN-alpha-2a in PV, we performed prospective sequential quantitative evaluation of the percentage of mutated JAK2 allele (%V617F) by real-time polymerase chain reaction (PCR). The %V617F decreased in 24 (89%) of 27 treated patients, from a mean of 49% to a mean of 27% (mean decrease of 44%; P < .001), and no evidence for a plateau was observed. In one patient, mutant JAK2 was no longer detectable after 12 months. In 3 patients homozygous for the mutation, reappearance of 50% of wild-type allele was observed during treatment. The results seem to confirm the hypothesis that IFN-alpha preferentially targets the malignant clone in PV and show that %V617F assessment using a quantitative method may provide the first tool to monitor minimal residual disease in PV. This trial was registered at www.clinicaltrials.gov as #NCT00241241. |
| Starting Page | 67 |
| Ending Page | 87 |
| Page Count | 21 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/108/6/2037.full.pdf?sso-checked=true |
| PubMed reference number | 16709929v1 |
| Volume Number | 108 |
| Issue Number | 6 |
| Journal | Blood |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biological Markers Clone Eighty Nine Forty Nine Homozygote Interferon Alfa-2a Mutation Neoplasm, Residual Patients Polycythemia Vera Real-Time Polymerase Chain Reaction Registration peginterferon alfa-2a peginterferon alfa-2b type I interferon receptor |
| Content Type | Text |
| Resource Type | Article |
