NDLI: How I treat patients with polycythemia vera

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How I treat patients with polycythemia vera

Content Provider	Scilit
Author	Finazzi, Guido Barbui, Tiziano
Copyright Year	2007
Description	The clinical course of polycythemia vera (PV) is marked by a high incidence of thrombotic complications; fibrotic and leukemic disease transformations are additional causes of morbidity and mortality. Major predictors of vascular events are increasing age and previous thrombosis; leukocytosis and high JAK2 V617F allele burden are currently being investigated for additional prognostic value in this regard. Myelosuppressive drugs can reduce the rate of thrombosis, but there is concern that their use raises the risk of transformation into acute leukemia. To tackle this dilemma, a risk-oriented management strategy is recommended. Low-risk patients should be treated with phlebotomy and low-dose aspirin. Cytotoxic therapy is indicated in high-risk patients, and the drug of choice is hydroxyurea because of its efficacy in preventing thrombosis and low leukemogenicity. Interferon-alpha should be reserved for selected categories of patients due to high cost and toxicity. The demonstration of JAK2 V617F mutation in the vast majority of PV patients opens the avenue for the development of promising new molecularly targeted drugs.
Related Links	http://bloodjournal.hematologylibrary.org/content/109/12/5104.full.pdf
Ending Page	5111
Page Count	8
Starting Page	5104
DOI	10.1182/blood-2006-12-038968
Journal	Blood
Issue Number	12
Volume Number	109
Language	English
Publisher	American Society of Hematology
Publisher Date	2007-06-15
Access Restriction	Open
Subject Keyword	Hematology Efficacy Thrombosis Polycythemia Vera Risk Patients Jak2 V617f Journal: Blood (Vol- 121, Issue- 12)
Content Type	Text
Resource Type	Article

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