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Increased apoptosis in bone marrow B lymphocytes but not T lymphocytes in myelodysplastic syndrome
| Content Provider | Scilit |
|---|---|
| Author | Amin, Hesham M. Jilani, Iman Estey, Elihu H. Keating, Michael J. Dey, Amanda L. Manshouri, Taghi Kantarjian, Hagop M. Estrov, Zeev Cortes, Jorge E. Thomas, Deborah A. Giles, Francis J. Albitar, Maher |
| Copyright Year | 2003 |
| Description | The hallmark of myelodysplastic syndrome (MDS) is enhanced apoptosis in myeloid, erythroid, and megakaryocytic cells in the bone marrow leading to ineffective hematopoiesis. Recent studies suggested that immunological and microenvironmental factors play a role in the pathophysiology of this disease. We report a significant increase in apoptosis in bone marrow B lymphocytes in MDS as compared to that found in acute myeloid leukemia and healthy controls. Furthermore, we demonstrate that patients with refractory anemia with excess blasts in transformation (RAEB-T) had apoptosis levels in lymphocytes similar to those seen in other subtypes of MDS. Our findings suggest that the alterations in B lymphocytes in the form of increased apoptosis can be seen in MDS and support the concept that immune modulation plays a role in the pathophysiology of MDS. |
| Related Links | http://www.bloodjournal.org/content/102/5/1866.full.pdf |
| Ending Page | 1868 |
| Page Count | 3 |
| Starting Page | 1866 |
| DOI | 10.1182/blood-2003-01-0221 |
| Journal | Blood |
| Issue Number | 5 |
| Volume Number | 102 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2003-09-01 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Bone Marrow Lymphocytes Mds Increased Apoptosis Myelodysplastic Pathophysiology Myeloid Journal: Blood (Vol- 84, Issue- 5) |
| Content Type | Text |
| Resource Type | Article |
