Loading...
Please wait, while we are loading the content...
Similar Documents
Kit ligand improves in vitro erythropoiesis in myelodysplastic syndrome
| Content Provider | Scilit |
|---|---|
| Author | Backx, B. Broeders, L. Lowenberg, B. |
| Copyright Year | 1992 |
| Description | Erythropoiesis in response to erythropoietin (Epo) in myelodysplastic syndrome (MDS) in vitro and in vivo is severely impaired. We investigated the stimulative effect of c-kit ligand (KL) on the erythroid colony-forming abilities of bone marrow cells from 17 patients with MDS. The effects of normal donor-derived marrow were examined in comparison. Suppression of erythroid colony formation in MDS in response to Epo could not be restored by the addition of interleukin-3 (IL-3) to culture. In cultures dishes supplemented with KL, erythroid colony formation was dramatically enhanced, regarding both colony number and size. Colony-forming abilities by MDS progenitors were improved following costimulation with KL, particularly in refractory anemia (RA) and refractory anemia with ring sideroblasts (RARS); however, little enhancement was apparent following KL stimulation of marrow from patients with refractory anemia with excess of blasts (RAEB), refractory anemia with excess of blasts in transformation (RAEB-t), and chronic myelomonocytic leukemia (CMML). These results suggest that KL responsiveness of patients with low-risk MDS may still be intact, and that with progression to high-risk MDS, erythroid progenitors lose proliferative reactivity to both KL and Epo stimulation. KL may have a therapeutic role in restoring erythropoiesis in a subset of patients with MDS. |
| Related Links | https://ashpublications.org/blood/article-pdf/80/5/1213/225262/1213.pdf |
| Ending Page | 1217 |
| Page Count | 5 |
| Starting Page | 1213 |
| DOI | 10.1182/blood.v80.5.1213.bloodjournal8051213 |
| Journal | Blood |
| Issue Number | 5 |
| Volume Number | 80 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1992-09-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Bone Marrow Refractory Anemia Kit Mds Erythroid Raeb Blasts Myelodysplastic Journal: Blood (Vol- 82, Issue- 5) |
| Content Type | Text |
| Resource Type | Article |
