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Cutting Edge: Developmental Switches in Chemokine Responses During T Cell Maturation
| Content Provider | Scilit |
|---|---|
| Author | Campbell, James J. Pan, Junliang Butcher, Eugene C. |
| Copyright Year | 1999 |
| Description | We show that developmental transitions during thymocyte maturation are associated with dramatic changes in chemotactic responses to chemokines. Macrophage-derived chemokine, a chemokine expressed in the thymic medulla, attracts thymocytes only during a brief window of development, between the late cortical and early medullary stages. All medullary phenotypes (CD4 or CD8 single positive) but not immature thymocytes respond to the medullary stroma-expressed (and secondary lymphoid tissue-associated) chemokines secondary lymphoid-tissue chemokine and macrophage inflammatory protein-3β. The appearance of these responses is associated with the phenotypic stage of cortex to medulla migration and with up-regulation of mRNA for the receptors CCR4 (for macrophage-derived chemokine and thymus and activation-regulated chemokine) and CCR7 (for secondary lymphoid-tissue chemokine and macrophage inflammatory protein-3β). In contrast, most immature and medullary thymocytes migrate to thymus-expressed chemokine, an ability that is lost only with up-regulation of the peripheral homing receptor L-selectin during the latest stages of thymocyte maturation associated with export to the periphery. Developmental switches in chemokine responses may help regulate critical migratory events during T cell development. |
| Ending Page | 2357 |
| Page Count | 5 |
| Starting Page | 2353 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.163.5.2353 |
| Journal | The Journal of Immunology |
| Issue Number | 5 |
| Volume Number | 163 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 1999-09-01 |
| Access Restriction | Open |
| Subject Keyword | Thymocyte Maturation Associated |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
