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Cutting Edge: Profound Defect in T Cell Responses in TNF Receptor-Associated Factor 2 Dominant Negative Mice
| Content Provider | Scilit |
|---|---|
| Author | Cannons, Jennifer L. Bertram, Edward M. Watts, Tania H. |
| Copyright Year | 2002 |
| Description | TNFR-associated factor 2 (TRAF2) is an adapter protein that links several members of the TNFR family to downstream signaling pathways. Mice expressing a dominant negative form of TRAF2 in their lymphoid cells (TRAF2.DN mice) have a profound defect in T cell responses to allogeneic APC. In contrast, APC from wild-type or TRAF2.DN mice show an equivalent level of stimulation in a MLR. Ab production and class switch are unimpaired in TRAF2.DN mice. Thus, defects in the TRAF.DN mice appear to be limited to T cells. TRAF2.DN mice demonstrate an impaired T cell response to influenza virus, including decreased secondary expansion of IFN-γ-secreting T cells as well as a decrease in CTL activity. CD4 T cell production of IL-2 was also dramatically impaired in TRAF2.DN mice. These studies suggest an essential role of TRAF2-linked receptors in secondary CD4 and CD8 T cell responses and have important implications for transplantation. |
| Ending Page | 2831 |
| Page Count | 4 |
| Starting Page | 2828 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.169.6.2828 |
| Journal | The Journal of Immunology |
| Issue Number | 6 |
| Volume Number | 169 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2002-09-15 |
| Access Restriction | Open |
| Subject Keyword | Cell Responses Traf2.dn |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
