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Cutting Edge: The Silent Chemokine Receptor D6 Is Required for Generating T Cell Responses That Mediate Experimental Autoimmune Encephalomyelitis
| Content Provider | Scilit |
|---|---|
| Author | LiPing, Liu Graham, Gerard J. Damodaran, Anita Hu, Taofang Lira, Sergio A. Sasse, Margaret Canasto-Chibuque, Claudia Cook, Donald N. Ransohoff, Richard M. |
| Copyright Year | 2006 |
| Description | D6, a promiscuous nonsignaling chemokine binding molecule expressed on the lymphatic endothelium, internalizes and degrades CC chemokines, and $D6^{−/−}$ mice demonstrated increased cutaneous inflammation following topical phorbol ester or CFA injection. We report that $D6^{−/−}$ mice were unexpectedly resistant to the induction of experimental autoimmune encephalomyelitis due to impaired encephalitogenic responses. Following induction with myelin oligodendroglial glycoprotein (MOG) peptide 35–55 in CFA, $D6^{−/−}$ mice showed reduced spinal cord inflammation and demyelination with lower incidence and severity of experimental autoimmune encephalomyelitis attacks as compared with $D6^{+/+}$ littermates. In adoptive transfer studies, MOG-primed $D6^{+/−}$ T cells equally mediated disease in $D6^{+/+}$ or $D6^{−/−}$ mice, whereas cells from $D6^{−/−}$ mice transferred disease poorly to $D6^{+/−}$ recipients. Lymph node cells from MOG-primed $D6^{−/−}$ mice showed weak proliferative responses and made reduced IFN-γ but normal IL-5. $CD11c^{+}$ dendritic cells accumulated abnormally in cutaneous immunization sites of $D6^{−/−}$ mice. Surprisingly, D6, a “silent” chemokine receptor, supports immune response generation. |
| Ending Page | 21 |
| Page Count | 5 |
| Starting Page | 17 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.177.1.17 |
| Journal | The Journal of Immunology |
| Issue Number | 1 |
| Volume Number | 177 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2006-07-01 |
| Access Restriction | Open |
| Subject Keyword | Mice Showed Chemokine Receptor |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
