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Cutting Edge: Critical Role for CD5 in Experimental Autoimmune Encephalomyelitis: Inhibition of Engagement Reverses Disease in Mice
| Content Provider | Scilit |
|---|---|
| Author | Axtell, Robert C. Webb, Matthew S. Barnum, Scott R. Raman, Chander |
| Copyright Year | 2004 |
| Description | The induction phase of experimental autoimmune encephalomyelitis (EAE) in mice is T cell dependent and coreceptors that regulate T cell activation modulate disease development. We report here that mice lacking CD5, an important modulator of T cell activation, exhibit significantly delayed onset and decreased severity of EAE. The resistance to EAE in $CD5^{−/−}$ mice was not due to the inability of T cells to respond efficiently to stimulation with $MOG_{35–55}$ but was associated with the presence of elevated frequency of apoptotic activated T cells in spleens and DLN. We also observed a net decrease in peripheral activated $CD4^{+}$ T cells in $CD5^{−/−}$ spleens and DLN 10 days after immunization. We further show that in vivo blockade of CD5 engagement after induction of EAE by soluble CD5-Fc, a treatment that induces elimination of activated T cells, promoted recovery from EAE. Our studies indicate that CD5 regulates survival of activated T cells and provides a target for treatment of T cell-dependent autoimmune diseases such as multiple sclerosis. |
| Ending Page | 2932 |
| Page Count | 5 |
| Starting Page | 2928 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.173.5.2928 |
| Journal | The Journal of Immunology |
| Issue Number | 5 |
| Volume Number | 173 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2004-09-01 |
| Access Restriction | Open |
| Subject Keyword | Activated T Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
