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Cutting Edge: In Vitro-Generated Tolerogenic APC Induce CD8+ T Regulatory Cells That Can Suppress Ongoing Experimental Autoimmune Encephalomyelitis
| Content Provider | Scilit |
|---|---|
| Author | Faunce, Douglas E. Terajewicz, Ania Stein-Streilein, Joan |
| Copyright Year | 2004 |
| Description | APC exposed to TGFβ2 and Ag (tolerogenic APC) promote peripheral Ag-specific tolerance via the induction of $CD8^{+}$ T regulatory cells capable of suppressing Th1 and Th2 immunity. We postulated that tolerogenic APC might reinstate tolerance toward self-neuronal Ags and ameliorate ongoing experimental autoimmune encephalomyelitis (EAE). Seven days after immunization with myelin basic protein (MBP), mice received MBP-specific tolerogenic APC, and EAE was evaluated clinically. To test for the presence and the phenotype of T regulatory cells, CD4 and/or CD8 T cells from tolerogenic APC-treated mice were transferred to naive mice before their immunization with MBP. The MBP-specific tolerogenic APC decreased both the severity and incidence of ongoing EAE. Tolerance to self-neuronal Ags was induced in naive recipient mice via adoptive transfer of $CD8^{+}$, but not $CD4^{+}$ T cells. Rational use of in vitro-generated tolerogenic APC may lead to novel therapy for autoimmune disease. |
| Ending Page | 1995 |
| Page Count | 5 |
| Starting Page | 1991 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.172.4.1991 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/172/4/1991.full.pdf |
| Journal | The Journal of Immunology |
| Issue Number | 4 |
| Volume Number | 172 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2004-02-15 |
| Access Restriction | Open |
| Subject Keyword | Tolerogenic Apc |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
