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Induction of CD4 T Cell Changes in Murine AIDS Is Dependent on Costimulation and Involves a Dysregulation of Homeostasis
| Content Provider | Scilit |
|---|---|
| Author | Yen, Michael H. Lepak, Nancy Swain, Susan L. |
| Copyright Year | 2002 |
| Description | Strong CD4 T cell activation and proliferation are seen in susceptible mice infected with the murine retroviral inoculum, LP-BM5, which produces an immunodeficiency syndrome called murine AIDS (MAIDS). We developed a short term adoptive transfer model of MAIDS to examine the requirements for the CD4 T cell response. Naive CD4 T cells from uninfected donors responded quickly after adoptive transfer into MAIDS-infected hosts, becoming activated and proliferating within several days. Using blocking mAbs to costimulatory ligands and CD4 T cells deficient in expression of their receptors, we found that the CD4 T cell response requires CD28:B7.1/B7.2 interactions, but not CTLA4 or CD40-CD40 ligand interactions. Naive CD4 T cells did not respond in H-2M-deficient mice with MAIDS, suggesting that disease requires recognition of self peptide-MHC complexes. The self MHC-dependent division and accumulation of large numbers of CD4 T cells suggest that MAIDS involves a disruption of the balance of homeostatic signals. Supporting this hypothesis, CD4 T cells from mice with MAIDS failed to regulate the homeostatic division of naive CD4 T cells in a cotransfer model. Thus, a combination of up-regulation of costimulatory ligands and disruption of homeostatic control may be responsible for CD4 lymphoproliferation in MAIDS. |
| Ending Page | 731 |
| Page Count | 10 |
| Starting Page | 722 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.169.2.722 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/169/2/722.full.pdf |
| Journal | The Journal of Immunology |
| Issue Number | 2 |
| Volume Number | 169 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2002-07-15 |
| Access Restriction | Open |
| Subject Keyword | Cd4 T Cells Naive Cd4 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
