NDLI: Impaired TCR-Mediated Induction of Ki67 by Naive CD4+ T Cells Is Only Occasionally Corrected by Exogenous IL-2 in HIV-1 Infection

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Impaired TCR-Mediated Induction of Ki67 by Naive CD4+ T Cells Is Only Occasionally Corrected by Exogenous IL-2 in HIV-1 Infection

Content Provider	Scilit
Author	Sieg, Scott F. Bazdar, Douglas A. Lederman, Michael M.
Copyright Year	2003
Description	Perturbations in naive T cell homeostasis and function may play a major role in the immunodeficiency that accompanies HIV infection. By examining naive $CD4^{+}$ T cell function on a single cell basis, we provide evidence that these cells have significant qualitative defects in HIV disease. Ki67, a molecule expressed during cell cycle progression, is induced less efficiently among naive $CD4^{+}$ T cells from HIV-infected individuals following activation with anti-TCR Ab. The impairment in Ki67 expression is evident even when a separate function, CD62L down-modulation, is within normal ranges. Moreover, the defects in Ki67 induction are only sometimes corrected by the addition of rIL-2 to cell cultures. An initial assessment of IL-2 unresponsiveness in cells from selected HIV-infected individuals suggests that the defect is not a consequence of impaired IL-2R expression or IL-2R signaling capability. Qualitative defects in naive T cells that cannot be routinely corrected by IL-2 have significant implications for disease pathogenesis and for strategies using IL-2 as a vaccine adjuvant in HIV disease.
Ending Page	5214
Page Count	7
Starting Page	5208
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.171.10.5208
Journal	The Journal of Immunology
Issue Number	10
Volume Number	171
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2003-11-15
Access Restriction	Open
Subject Keyword	Cell Cultures Naive Cd4 Naive T Cell
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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