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The Role of B7 Costimulation in CD4/CD8 T Cell Homeostasis
| Content Provider | Scilit |
|---|---|
| Author | Yu, Xiang Fournier, Sylvie Allison, James P. Sharpe, Arlene H. Hodes, Richard J. |
| Copyright Year | 2000 |
| Description | The effect of B7-mediated costimulation on T cell homeostasis was examined in studies of B7-1 (CD80) and B7-2 (CD86) transgenic as well as B7-deficient mice. B7 overexpression in transgenic mice resulted in marked polyclonal peripheral T cell hyperplasia accompanied by skewing toward an increased proportion of CD8 single-positive cells and a decreased proportion of CD4 single-positive cells in thymus and more markedly in peripheral T cells. B7-induced T cell expansion was dependent on both CD28 and TCR expression. Transgenic overexpression of B7-1 or B7-2 resulted in down-regulation of cell surface CD28 on thymocytes and peripheral T cells through a mechanism mediated by intercellular interaction. Mice deficient in B7-1 and B7-2 exhibited changes that were the reciprocal of those observed in B7-overexpressing transgenics: a marked increase in the CD4/CD8 ratio in peripheral T cells and an increase in cell surface CD28 in thymus and peripheral T cells. These reciprocal effects of genetically engineered increase or decrease in B7 expression indicate that B7 costimulation plays a physiological role in the regulation of $CD4^{+}$ and $CD8^{+}$ T cell homeostasis. |
| Ending Page | 3553 |
| Page Count | 11 |
| Starting Page | 3543 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.164.7.3543 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/164/7/3543.full.pdf |
| Journal | The Journal of Immunology |
| Issue Number | 7 |
| Volume Number | 164 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2000-04-01 |
| Access Restriction | Open |
| Subject Keyword | Cd4/cd8 B7 Costimulation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
