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Cutting Edge: Critical Role for PYCARD/ASC in the Development of Experimental Autoimmune Encephalomyelitis
| Content Provider | Scilit |
|---|---|
| Author | Shaw, Patrick J. Lukens, John R. Burns, Samir Chi, Hongbo McGargill, Maureen A. Kanneganti, Thirumala-Devi |
| Copyright Year | 2010 |
| Description | Multiple sclerosis is an autoimmune disease in which self-reactive T cells attack oligodendrocytes that myelinate axons in the CNS. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, is dependent on caspase-1; however, the role of Nod-like receptors upstream of caspase-1 is unknown. Danger- and pathogen-associated molecular patterns activate Nod-like receptor 3, which activates caspase-1 through the adaptor protein, apoptosis-associated speck-like protein containing CARD (ASC). We report that the progression of EAE is dependent on ASC and caspase-1 but not Nod-like receptor 3. $ASC^{−/−}$ mice were even more protected from the progression of EAE than were $caspase-1^{−/−}$ mice, suggesting that an inflammasome-independent function of ASC contributes to the progression of EAE. We found that $CD4^{+}$ T cells deficient in ASC exhibited impaired survival; accordingly, $ASC^{−/−}$ mice had fewer myelin oligodendrocyte glycoprotein–specific T cells in the draining lymph nodes and CNS. |
| Ending Page | 4614 |
| Page Count | 5 |
| Starting Page | 4610 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1000217 |
| Journal | The Journal of Immunology |
| Issue Number | 9 |
| Volume Number | 184 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2010-05-01 |
| Access Restriction | Open |
| Subject Keyword | Caspase-1 Multiple Sclerosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
