NDLI: Prenatal nicotine exposure induced GDNF/c-Ret pathway repression-related fetal renal dysplasia and adult glomerulosclerosis in male offspring

Please wait, while we are loading the content...

Exocyclic DNA adducts in sheep with skeletal fluorosis resident in the proximity of the Portoscuso-Portovesme industrial estate on Sardinia Island, Italy

Do poly(epsilon-caprolactone) lipid-core nanocapsules induce oxidative or inflammatory damage after in vivo subchronic treatment?

Neurobehavioral changes induced by di(2-ethylhexyl) phthalate and the protective effects of vitamin E in Kunming mice

Inhibition of the flavonoid extract from silkworm cocoons on DMBA/UVB-induced skin damage and tumor promotion in BALB/c mice

Effects of monoolein-based cubosome formulations on lipid droplets and mitochondria of HeLa cells

Biocompatibility studies on lanthanum oxide nanoparticles

Prenatal nicotine exposure induced GDNF/c-Ret pathway repression-related fetal renal dysplasia and adult glomerulosclerosis in male offspring

Gambogic acid suppresses cytochrome P450 3A4 by downregulating pregnane X receptor and up-regulating DEC1 in human hepatoma HepG2 cells

Umbelliferone β-d-galactopyranoside exerts an anti-inflammatory effect by attenuating COX-1 and COX-2

A new animal model for Polygonum multiflorum Thunb-induced liver injury in rats and its potential mechanisms

Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo

Back cover

Toxicology Research Vol - 4 Issue - 3

Toxicology Research Vol - 4 Issue - 2

Toxicology Research Vol - 4 Issue - 1

Toxicology Research Vol -3

Toxicology Research Vol -2

Toxicology Research Vol -1

Prenatal nicotine exposure induced GDNF/c-Ret pathway repression-related fetal renal dysplasia and adult glomerulosclerosis in male offspring

Content Provider	Royal Society of Chemistry (RSC)
Author	Zuo, Na Wang, Hui Yang, Shuailong He, Zheng Ao, Ying Hu, Shuangshuang Sun, Zhaoxia
Copyright Year	2015
Abstract	This study aimed at investigating whether prenatal nicotine exposure (PNE) could disrupt fetal kidney development and then induce glomerulosclerosis in adult offspring, and to explore its underlying mechanisms. A rat model of intrauterine growth retardation (IUGR) was established by subcutaneous injection with nicotine (1 mg kg−1) to pregnant rats twice a day from gestational day (GD) 9 to GD20. Male fetuses and adult offspring were sacrificed at GD20 and postnatal week 24 (PW24) respectively, and blood and kidneys were collected for analysis. The results indicated that, in the PNE fetuses, the widths of the renal cortical zone and the nephrogenic zone were both significantly reduced. Meanwhile, some glomeruli presented a dilated Bowman's space and a shrunken glomerular tuft, accompanied by the ultrastructural changes, such as extensive fusion and effacement of podocyte foot processes as well as swollen and vacuolar degeneration of the mitochondria. Moreover, in fetal kidneys, the mRNA and protein expression of AT1R and AT2R were both inhibited by PNE, associated with the repression of glial cell line derived neurotrophic factor/c-Ret tyrosine kinase receptor (GDNF/c-Ret) signaling pathway-related genes and GDNF protein. In adult offspring of the PNE group, the body weight and kidney weight were decreased, whereas the levels of serum creatinine and urea nitrogen were increased or exhibited an increasing trend. The histological examinations revealed glomerular sclerosis, and q-PCR analysis indicated a marked alternation of renal AT1aR mRNA abundance as well as the AT1aR/AT2R ratio. These results suggested that PNE could induce fetal renal dysplasia associated with the suppression of the GDNF/c-Ret pathway and adult glomerulosclerosis in male offspring, and the dysregulation of renal ATR might be involved in the underlying mechanisms.
Starting Page	1045
Ending Page	1058
Page Count	14
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	4
Issue Number	4
Journal	Toxicology Research
DOI	10.1039/c5tx00040h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Glomerulosclerosis Creatinine Glial cell line-derived neurotrophic factor Dysplasia PNE Angiotensin II receptor type 1 Neuroglia Neurotrophic factors Nitrogen Protein Kidney Podocyte Mitochondrion Intrauterine growth restriction Tyrosine kinase Urea Messenger RNA Glomerulus (kidney) Subcutaneous tissue Ataxia telangiectasia and Rad3 related ATR Nicotine Kidney development Real-time polymerase chain reaction
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

ATR (ataxia telangiectasia and Rad3 related)

Quantitative Phosphoproteomics of the Ataxia Telangiectasia-Mutated (ATM) and Ataxia Telangiectasia-Mutated and Rad3-related (ATR) Dependent DNA Damage Response in

Recent Advances in Synergistic Antitumor Effects Exploited from the Inhibition of Ataxia Telangiectasia and RAD3-Related Protein Kinase (ATR)

Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers

Molecular dynamics-based self-organizing molecular field analysis on 3-amino-6-arylpyrazines as the ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibitors

Ataxia telangiectasia and rad3 related (ATR)-promyelocytic leukemia protein (PML) pathway of the DNA damage response in the brain of rats administered arsenic trioxide

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

UV-induced Ataxia-telangiectasia-mutated and Rad3-related (ATR) Activation Requires Replication Stress

Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells

Prenatal nicotine exposure induced GDNF/c-Ret pathway repression-related fetal renal dysplasia and adult glomerulosclerosis in male offspring

Similar Documents

ATR (ataxia telangiectasia and Rad3 related)

Quantitative Phosphoproteomics of the Ataxia Telangiectasia-Mutated (ATM) and Ataxia Telangiectasia-Mutated and Rad3-related (ATR) Dependent DNA Damage Response in

Recent Advances in Synergistic Antitumor Effects Exploited from the Inhibition of Ataxia Telangiectasia and RAD3-Related Protein Kinase (ATR)

Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers

Molecular dynamics-based self-organizing molecular field analysis on 3-amino-6-arylpyrazines as the ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibitors

Ataxia telangiectasia and rad3 related (ATR)-promyelocytic leukemia protein (PML) pathway of the DNA damage response in the brain of rats administered arsenic trioxide

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

UV-induced Ataxia-telangiectasia-mutated and Rad3-related (ATR) Activation Requires Replication Stress

Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells

Prenatal nicotine exposure induced GDNF/c-Ret pathway repression-related fetal renal dysplasia and adult glomerulosclerosis in male offspring