NDLI: Identification and quantification of biomarkers to confirm the poisoning by Ginkgo biloba seeds in a 2-year-old boy

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New approaches for biomonitoring exposure to the human carcinogen aristolochic acid

Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity

The puzzle of toxicity of gold nanoparticles. The case-study of HeLa cells

In vitro models for neurotoxicology research

Molecular modeling and spectroscopic study of quinone–protein adducts: insight into toxicity, selectivity, and reversibility

CpG site-specific RASSF1a hypermethylation is associated with occupational PAH exposure and genomic instability

Interleukin-6 promotes dietary carcinogen-induced DNA damage in colorectal cancer cells

Dose–response assessment of the dermal toxicity of triclosan in B6C3F1 mice

Behavioral and dopaminergic damage induced by acute iron toxicity in Caenorhabditis elegans

Toxicity mechanism of graphene oxide and nitrogen-doped graphene quantum dots in RBCs revealed by surface-enhanced infrared absorption spectroscopy

Participation of b^0,+ and B^0,+ systems in the transport of mercury bound to cysteine in intestinal cells

Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes

The Zishen Yutai pill shows no reproductive toxicity on embryo-fetal development in rats and rabbits

Identification and quantification of biomarkers to confirm the poisoning by Ginkgo biloba seeds in a 2-year-old boy

Perfluorooctane sulfonate induces apoptosis of hippocampal neurons in rat offspring associated with calcium overload

Metabolomics reveals disturbed metabolic pathways in human lung epithelial cells exposed to airborne fine particulate matter

Metabolomic profiling of emodin-induced cytotoxicity in human liver cells and mechanistic study

Two generation reproduction and teratogenicity studies of feeding diaveridine in Wistar rats

Toxicological assessment of PEG functionalized f-block rare earth phosphate nanorods

Differential effects of p38 and JNK activation by GSK3 on cadmium-induced autophagy and apoptosis

Exocyclic DNA adducts in sheep with skeletal fluorosis resident in the proximity of the Portoscuso-Portovesme industrial estate on Sardinia Island, Italy

Do poly(epsilon-caprolactone) lipid-core nanocapsules induce oxidative or inflammatory damage after in vivo subchronic treatment?

Neurobehavioral changes induced by di(2-ethylhexyl) phthalate and the protective effects of vitamin E in Kunming mice

Inhibition of the flavonoid extract from silkworm cocoons on DMBA/UVB-induced skin damage and tumor promotion in BALB/c mice

Effects of monoolein-based cubosome formulations on lipid droplets and mitochondria of HeLa cells

Biocompatibility studies on lanthanum oxide nanoparticles

Prenatal nicotine exposure induced GDNF/c-Ret pathway repression-related fetal renal dysplasia and adult glomerulosclerosis in male offspring

Gambogic acid suppresses cytochrome P450 3A4 by downregulating pregnane X receptor and up-regulating DEC1 in human hepatoma HepG2 cells

Umbelliferone β-d-galactopyranoside exerts an anti-inflammatory effect by attenuating COX-1 and COX-2

A new animal model for Polygonum multiflorum Thunb-induced liver injury in rats and its potential mechanisms

Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo

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Identification and quantification of biomarkers to confirm the poisoning by Ginkgo biloba seeds in a 2-year-old boy

Content Provider	Royal Society of Chemistry (RSC)
Author	Lorenzo, Chiara Di Lüde, Saskia Dechend, Margot Ceschi, Alessandro Colombo, Francesca Bianchetti, Mario G. Restani, Patrizia Frigerio, Gianfranco Valoti, Ermanno
Copyright Year	2015
Abstract	The seeds of Ginkgo biloba are commonly eaten in Japan, Korea and China, but it is important to know that they can be responsible for poisoning, especially in young children. Poisoning due to Ginkgo biloba seeds must also be considered as a possible clinical event in European countries, where Asian cuisine has recently become popular. This paper reports the case of a 23-months-old previously healthy male child who experienced two afebrile tonic-clonic seizures after the consumption of an unknown amount of Ginkgo seeds. The poisoning was identified by searching both in blood and urine for 4′-O-methylpyridoxine (MPN) as a specific biomarker for ginkgo poisoning, using an optimized and validated HPLC method with fluorimetric detection. The MPN concentrations in serum were 16.5 and 6.2 ng mL−1 14 and 20 hours after the exposure, respectively, while the urine concentration was below the limit of detection (1.35 ng mL−1). The involvement of ginkgo seeds in the described poisoning was confirmed by searching ginkgolide terpene lactones in urine, where the ratio between excreted ginkgolide A : B : C was 1 : 40 : 2. The analytical data obtained by looking for biomarkers in serum and urine demonstrate that even low values of MPN/ginkgolide concentration can be responsible for convulsions and other adverse effects.
Starting Page	922
Ending Page	930
Page Count	9
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	4
Issue Number	4
Journal	Toxicology Research
DOI	10.1039/c5tx00016e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ginkgo biloba Urine South Korea Biomarker Terpene The Seeds Asian cuisine Japan China Generalised tonic-clonic seizure High-performance liquid chromatography Korea
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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Identification and quantification of biomarkers to confirm the poisoning by Ginkgo biloba seeds in a 2-year-old boy

Pressurized water extraction (PWE) of terpene trilactones from Ginkgo biloba leaves

Ginkgo biloba Seeds—An Environmental Pollutant or a Functional Food

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Generalised seizure due to terfenadine.

First Tonic-Clonic Seizure: Treatment and Prognosis

Severe metabolic acidosis after a single tonic-clonic seizure

Identification and quantification of biomarkers to confirm the poisoning by Ginkgo biloba seeds in a 2-year-old boy

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