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New approaches for biomonitoring exposure to the human carcinogen aristolochic acid

Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity

The puzzle of toxicity of gold nanoparticles. The case-study of HeLa cells

In vitro models for neurotoxicology research

Molecular modeling and spectroscopic study of quinone–protein adducts: insight into toxicity, selectivity, and reversibility

CpG site-specific RASSF1a hypermethylation is associated with occupational PAH exposure and genomic instability

Interleukin-6 promotes dietary carcinogen-induced DNA damage in colorectal cancer cells

Dose–response assessment of the dermal toxicity of triclosan in B6C3F1 mice

Behavioral and dopaminergic damage induced by acute iron toxicity in Caenorhabditis elegans

Toxicity mechanism of graphene oxide and nitrogen-doped graphene quantum dots in RBCs revealed by surface-enhanced infrared absorption spectroscopy

Participation of b^0,+ and B^0,+ systems in the transport of mercury bound to cysteine in intestinal cells

Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes

The Zishen Yutai pill shows no reproductive toxicity on embryo-fetal development in rats and rabbits

Identification and quantification of biomarkers to confirm the poisoning by Ginkgo biloba seeds in a 2-year-old boy

Perfluorooctane sulfonate induces apoptosis of hippocampal neurons in rat offspring associated with calcium overload

Metabolomics reveals disturbed metabolic pathways in human lung epithelial cells exposed to airborne fine particulate matter

Metabolomic profiling of emodin-induced cytotoxicity in human liver cells and mechanistic study

Two generation reproduction and teratogenicity studies of feeding diaveridine in Wistar rats

Toxicological assessment of PEG functionalized f-block rare earth phosphate nanorods

Differential effects of p38 and JNK activation by GSK3 on cadmium-induced autophagy and apoptosis

Exocyclic DNA adducts in sheep with skeletal fluorosis resident in the proximity of the Portoscuso-Portovesme industrial estate on Sardinia Island, Italy

Do poly(epsilon-caprolactone) lipid-core nanocapsules induce oxidative or inflammatory damage after in vivo subchronic treatment?

Neurobehavioral changes induced by di(2-ethylhexyl) phthalate and the protective effects of vitamin E in Kunming mice

Inhibition of the flavonoid extract from silkworm cocoons on DMBA/UVB-induced skin damage and tumor promotion in BALB/c mice

Effects of monoolein-based cubosome formulations on lipid droplets and mitochondria of HeLa cells

Biocompatibility studies on lanthanum oxide nanoparticles

Prenatal nicotine exposure induced GDNF/c-Ret pathway repression-related fetal renal dysplasia and adult glomerulosclerosis in male offspring

Gambogic acid suppresses cytochrome P450 3A4 by downregulating pregnane X receptor and up-regulating DEC1 in human hepatoma HepG2 cells

Umbelliferone β-d-galactopyranoside exerts an anti-inflammatory effect by attenuating COX-1 and COX-2

A new animal model for Polygonum multiflorum Thunb-induced liver injury in rats and its potential mechanisms

Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo

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Biocompatibility studies on lanthanum oxide nanoparticles

Content Provider	Royal Society of Chemistry (RSC)
Author	Haribabu, S. Brabu, B. Navaneethakrishnan, K. R. Thangapandiyan, M. Murugan, S. S. Kumaravel, T. S. Revathy, M. Gopalakrishnan, C. Anitha, S.
Copyright Year	2015
Abstract	Lanthanum oxide nanoparticles (LONP), a rare earth metal oxide, have unique properties that make them a suitable candidate for several biomedical applications. We investigated certain key in vitro and in vivo biocompatibility endpoints on LONP. LONP were cytotoxic in in vitro assays and predominantly exerted their action via release of reactive oxygen species. These nanoparticles were neither irritants nor sensitizers in a rabbit model. LONP extracts did not exert any acute systemic toxicity effects in mice. On the other hand LONP exerted toxicity to the liver following oral administration, suggesting that these particles are absorbed from the gastrointestinal (GI) tract and deposited in the hepatobiliary system. LONP did not induce any mutation in the Ames test both in the presence or absence of S-9. These observations provide a base line biocompatibility and toxicity data on LONP. The current findings will also be useful in defining standards for nanoparticle containing devices.
Starting Page	1037
Ending Page	1044
Page Count	8
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	4
Issue Number	4
Journal	Toxicology Research
DOI	10.1039/c4tx00198b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Boron group Biliary tract Reactive oxygen species Ames test Nanoparticle LONP Liver Biocompatibility Cytotoxicity Mutation Lanthanum oxide
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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Biocompatibility studies on lanthanum oxide nanoparticles

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