NDLI: Biochemical alterations in kidneys of infant and adult male rats due to exposure to the neonicotinoid insecticides imidacloprid and clothianidin

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Toxicology Research Vol - 3 Issue - 4

Toxicology Research Vol - 3 Issue - 3

Toxicology Research Vol - 3 Issue - 2

Toxicology Research Vol - 3 Issue - 1

Toxicology Research Vol -2

Toxicology Research Vol -1

Biochemical alterations in kidneys of infant and adult male rats due to exposure to the neonicotinoid insecticides imidacloprid and clothianidin

Content Provider	Royal Society of Chemistry (RSC)
Author	Ozsahin, Ayse Dilek Bal, Ramazan Yılmaz, Okkes
Copyright Year	2014
Abstract	Imidacloprid (IMI) and clothianidin (CTD) are the most important of the neonicotinoid insecticides known to target the nicotinic acetylcholine receptor (nAChR) in insects and, potentially, in mammals. In the present study, we aimed to investigate if daily oral administration of IMI and CTD at low subchronic doses for 90 days has any deleterious effects on the biochemical parameters of infant and adult male rats. Animals were randomly divided into five groups of seven rats each: controls, IMI-infant and IMI-adult treatments at 4 mg per kg BW per day, and CTD-infant and CTD-adult treatments at 12 mg per kg BW per day by oral gavage. Kidneys of rats exposed to IMI and CTD showed biochemical changes. Based on the biochemical studies it is evident that IMI and CTD produce significant effects in male rats at 4 and 12 mg per kg per day of exposure. In conclusion, the present animal experiments revealed that the treatment with IMI and CTD at NOAEL (no observed adverse effect level) dose-levels causes changes in kidney biochemical parameters which seem to be dependent on the pesticide and age of the animal (infant or adult).
Starting Page	324
Ending Page	330
Page Count	7
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	3
Issue Number	5
Journal	Toxicology Research
DOI	10.1039/c4tx00006d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Neonicotinoid CTD Force-feeding IMI Pesticide Nicotinic acetylcholine receptor Imidacloprid Clothianidin Kidney 90 Days (film)
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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