NDLI: Neonicotinoid insecticides mode of action on insect nicotinic acetylcholine receptors using binding studies

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Neonicotinoid insecticides mode of action on insect nicotinic acetylcholine receptors using binding studies

Content Provider	Scilit
Author	Taillebois, Emiliane Cartereau, Alison Jones, Andrew K. Thany, Steeve H.
Copyright Year	2018
Description	Journal: Pesticide Biochemistry and Physiology Nicotinic acetylcholine receptors (nAChRs) are the main target of neonicotinoid insecticides, which are widely used in crop protection against insect pests. Electrophysiological and molecular approaches have demonstrated the presence of several nAChR subtypes with different affinities for neonicotinoid insecticides. However, the precise mode of action of neonicotinoids on insect nAChRs remains to be elucidated. Radioligand binding studies with $[^{3}$H]-α-bungarotoxin and $[^{3}$H]-imidacloprid have proved instructive in understanding ligand binding interactions between insect nAChRs and neonicotinoid insecticides. The precise binding site interactions have been established using membranes from whole body and specific tissues. In this review, we discuss findings concerning the number of nAChR binding sites against neonicotinoid insecticides from radioligand binding studies on native tissues. We summarize the data available in the literature and compare the binding properties of the most commonly used neonicotinoid insecticides in several insect species. Finally, we demonstrate that neonicotinoid-nAChR binding sites are also linked to biological samples used and insect species.
Related Links	https://radar.brookes.ac.uk/radar/file/c59cbdb5-d171-49e0-b0e4-101c261c72ed/1/fulltext.pdf
Ending Page	66
Page Count	8
Starting Page	59
ISSN	00483575
DOI	10.1016/j.pestbp.2018.04.007
Journal	Pesticide Biochemistry and Physiology
Volume Number	151
Language	English
Publisher	Elsevier BV
Publisher Date	2018-10-01
Access Restriction	Open
Subject Keyword	Journal: Pesticide Biochemistry and Physiology Nicotinic Receptors Neonicotinoid Insecticides Binding Studies
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Agronomy and Crop Science

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