NDLI: Vinclozolin exposure throughout pregnancy and its developmental toxicity

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Vinclozolin exposure throughout pregnancy and its developmental toxicity

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Toxicology Research Vol - 3 Issue - 4

Toxicology Research Vol - 3 Issue - 3

Toxicology Research Vol - 3 Issue - 2

Toxicology Research Vol - 3 Issue - 1

Toxicology Research Vol -2

Toxicology Research Vol -1

Vinclozolin exposure throughout pregnancy and its developmental toxicity

Content Provider	Royal Society of Chemistry (RSC)
Author	Karacaoğlu, Elif Selmanoğlu, Güldeniz Süloğlu, Aysun Kılıç Koçkaya, Evrim Arzu
Copyright Year	2014
Abstract	It is well known that vinclozolin, commonly used in greenhouse cultivation, causes alterations in the fetal reproductive system. There were no reports about the effects of vinclozolin exposure on the placenta during gestation, therefore, in this study 50 and 100 mg kg−1 body weight per day (bw d−1) doses of vinclozolin were administered by oral gavage to pregnant rats during gestation. They were then subjected to a caesarean section on gestation day 20. Maternal and fetal liver, kidney, heart, thymus, brain, and placenta were examined histopathologically, the placenta and liver tissues were stained immunohistochemically for Vascular Endothelial Growth Factor (VEGF). Morphometric analyses of fetal body lengths, placental measurements, and fetal skeletal staining were performed. The decrease in the placental weight and placental index was significant in the treatment groups. Degenerations in labyrinth region and spongiotrophoblast were detected in the 100 mg kg−1 bw d−1 vinclozolin group. Mononuclear cell infiltration, cellular degeneration and edema in maternal liver samples and an increase in the number of megakaryocytes, cellular degeneration and congestion in fetal liver samples were observed in the treatment groups. VEGF staining was dense in trophoblastic giant cells and spongiotrophoblasts, and less dense in the labyrinth region. VEGF staining increased especially around the central vein in maternal liver. Minor alterations were also observed in the fetal skeleton measurements. These results demonstrated that vinclozolin and/or its metabolites transport to the placenta and induce histopathological changes in the placenta, and maternal and fetal tissues.
Starting Page	375
Ending Page	383
Page Count	9
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	3
Issue Number	5
Journal	Toxicology Research
DOI	10.1039/c4tx00037d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Edema Force-feeding Placenta Liver Gestation Vascular endothelial growth factor Kidney Thymus
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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Vinclozolin exposure throughout pregnancy and its developmental toxicity

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