NDLI: Surface-grafted zwitterionic polymers as platforms for functional supported phospholipid membranes

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Surface-grafted zwitterionic polymers as platforms for functional supported phospholipid membranes

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Surface-grafted zwitterionic polymers as platforms for functional supported phospholipid membranes

Content Provider	Royal Society of Chemistry (RSC)
Author	Ma, Yujie Memesa, Mine Vancso, G. Julius Meszyńska, Anna Santonicola, M. Gabriella
Copyright Year	2012
Abstract	Polymer brushes grafted from surfaces using controlled polymerization techniques, most notably surface-initiated atom-transfer radical polymerization (SI-ATRP), provide robust and reproducible platforms with precise control of surface properties. These platforms are especially useful in biologically oriented applications involving the confinement of membrane proteins onto solid supports, including screening of pharmaceuticals and biosensing. Here we investigate a tunable zwitterion-based polymeric interface that can guide the assembly of neutral lipid membranes with high mechanical stability and reproducibility on various synthetic materials. By controlling the polymer architecture using ATRP, we show that phospholipid membranes can be made to self-assemble on thin layers of charge-balanced poly(sulfobetaine methacrylate) from fusion of DOPC vesicles under physiological conditions. The self-assembly kinetics and functionality of the polymer-supported lipid membranes are investigated using various surface sensitive techniques, including surface plasmon resonance, fluorescence microscopy, and atomic force microscopy. The growth of zwitterionic polymer layers with controlled length and grafting density allows for modulation of the adhesion of the lipid bilayers to surfaces, thus offering unique advantages for the design and synthesis of bioactive surfaces.
Starting Page	1556
Ending Page	1562
Page Count	7
File Format	HTM / HTML PDF
ISSN	1744683X
Volume Number	8
Issue Number	5
Journal	Soft Matter
DOI	10.1039/c1sm06709e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Self-assembly Atomic-force microscopy Radical polymerization Polymerization Phospholipid Polymer Surface plasmon resonance Fluorescence microscope Surface plasmon Grafting Lipid ATRP
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics

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Synthesis of End-Functionalized Lipopolymers and Their Characterization with Regard to Polymer-Supported Lipid Membranes

Surface-grafted zwitterionic polymers as platforms for functional supported phospholipid membranes

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