NDLI: The role of palmitic acid in pulmonary surfactant systems by Langmuir monolayer study: Lipid

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Soft Matter Vol - 7 Issue - 19

Soft Matter Vol - 7 Issue - 9

Soft Matter Vol - 7 Issue - 8

Soft Matter Vol - 7 Issue - 7

Soft Matter Vol - 7 Issue - 6

Soft Matter Vol - 7 Issue - 5

Soft Matter Vol - 7 Issue - 4

Soft Matter Vol - 7 Issue - 3

The role of palmitic acid in pulmonary surfactant systems by Langmuir monolayer study: Lipid–peptide interactions

Content Provider	Royal Society of Chemistry (RSC)
Author	Shibata, Osamu Nakahara, Hiromichi Shoyama, Yukihiro Lee, Sannamu
Copyright Year	2011
Abstract	Palmitic acid (PA) has been widely used as an useful and effective additive to pulmonary surfactants (PS) such as Survanta and Surfaxin. Moreover, PA has well-known biological and physicochemical properties, and its simple chemical structure allows its manufacture at low cost. However, the role and significance of PA in PS formulations are still controversial. In the present study, the PS model preparation containing PA has been investigated to clarify its additional effect (molecular recognition and interaction in particular) employing the Langmuir monolayer technique. The elucidation of the PA effect is performed by comparison with the data from its analogue (or homologue) lipids; i.e. three fatty acids and four fatty alcohols. The surface pressure (π)-molecular area (A) and surface potential (ΔV)−A isotherms for the eight DPPC/fatty lipid systems containing a PS model peptide (Hel 13-5) have been measured. In addition, the morphology and phase behavior are examined with in situ fluorescence and ex situatomic force microscopy. As a result, it is found that a balance between the hydrophilicity of the headgroup and the hydrophobicity of the tail group in the lipids is an important factor in pulmonary functions. In particular, the dissociation degree of the fatty acids, which depends on the pH or the surface pH, strongly affects their electrostatic interaction with positively charged Hel 13-5. The chain length is also significant and the carbon number 16 is found to be most appropriate. The present molecular-level information on the interaction between the lipids and Hel 13-5 in the presence of DPPC indicates that PA takes on a hydrophile–lipophile balance suitable for the PS preparation.
Starting Page	11351
Ending Page	11359
Page Count	9
File Format	HTM / HTML PDF
ISSN	1744683X
Volume Number	7
Issue Number	24
Journal	Soft Matter
DOI	10.1039/c1sm06345f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Fluorescence Hydrophobe Dissociative Carbon Lipid Survanta Lucinactant Microscopy Carboxylic acid Beractant Irving Langmuir Hel Peninsula Langmuir Molecular recognition Hydrophile Peptide DPPC Dipalmitoylphosphatidylcholine
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics

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