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Electrorheological fluids: smart soft matter and characteristics

Solvent-chirality selective organogelation by chiral aspartame lipids

Geometrical frustration of chiral ordering in cholesteric droplets

Stimulation of vigorous rotational flows and novel flow patterns using triaxial magnetic fields

Direct observation of particle rearrangement during cyclic stress hardening of magnetorheological gels

Thermo-responsive organic–inorganic hybrid vesicles with tunable membrane permeability

Multi-component hierarchically structured polymer brushes

Using the dynamics of fluorescent cations to probe and map charged surfaces

Thermorheological behavior of coexisting physical networks: combining SAFIN and SAMIN organogels

A colloidal supra-structure of responsive microgels as a potential cell scaffold

Protein binding to soft polymeric layers: a quantitative study by fluorescence spectroscopy

Dynamics of DNA-programmable nanoparticle crystallization: gelation, nucleation and topological defects

Granular polymer composites

Minimum free energy paths for a nanoparticle crossing the lipid membrane

Foam film study of albumin inhibited lung surfactant preparations: effect of added hydrophilic polymers

Hydration forces as a tool for the optimization of core–shell nanoparticle vectors for cancer gene therapy

Buckling-induced structural transition during the drying of a polymeric latex droplet on a solid surface

High cellulose nanowhisker content composites through cellosize bonding

A vibration-charge-induced unidirectional transport of water molecules in confined nanochannels

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Lyotropic phase behavior of polymer-coated iron oxide nanoparticles

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Foam film study of albumin inhibited lung surfactant preparations: effect of added hydrophilic polymers

Content Provider	Royal Society of Chemistry (RSC)
Author	Tsanova, Asya Lalchev, Zdravko Georgiev, Georgi As. Jordanova, Albena Vassilieff, Christian
Copyright Year	2012
Abstract	In Adult and Acute Respiratory Distress Syndrome (ARDS) the concentration of albumin in the alveolar fluid reaches 25–100 mg ml−1. Due to its high adsorption rate albumin adsorbs at the air/water interface making it inaccessible for the lung surfactant (LS). LS inactivation can be prevented by hydrophilic polymers due to depletion attraction osmotic pressure or other specific action. Two commercially available lung surfactant preparations, LSP (Curosurf and Survanta), and four hydrophilic polymers (PEG, dextran, PVP, hyaluronic acid-HA) were investigated in control experiments at one (monolayer) and two interacting air/solution interfaces (foam film) under albumin free and albumin inactivated conditions. The established procedure to measure the minimal surface tension in successive compression–expansion cycles of monolayers revealed that minimal surface tension ≤10 mN m−1 for Survanta is achieved with PEG, PVP, and HA, while for Curosurf with dextran, PVP, and HA. This correlates with the observations of Lu et al., 2005. Foam film experiments with the microinterferometric method of Scheludko and Exerowa revealed the relative ability of the polymers to decrease the effect of albumin inhibition in restoring the formation of stable and homogeneous black films (thickness <17 nm). Stable black foam films are formed by Survanta with PEG, PVP, and HA, while by Curosurf with dextran, PVP, and HA. Kinetic data of Curosurf foam film thinning were interpreted to obtain values of the disjoining pressure. An interesting change from repulsion to attraction was observed at a thickness of appr. 100 nm. It may be explained by depletion attraction overcoming the steric repulsion. The magnitude of the depletion attraction was estimated.
Starting Page	12072
Ending Page	12079
Page Count	8
File Format	HTM / HTML PDF
ISSN	1744683X
Volume Number	8
Issue Number	48
Journal	Soft Matter
DOI	10.1039/c2sm25937k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Acute respiratory distress syndrome Exerowa Disjoining pressure Curosurf Albumin PVP Minimal surface Survanta Dextran Adsorption Pulmonary surfactant Beractant Pulmonary alveolus Hydrophile Scheludko Osmotic pressure ARDS
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics

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Drainage of Emulsion and Foam Films in Scheludko-exerowa Cells J.

195 Comparison of Incidences of All-Cause Mortality Between The Novel Surfactant, Surfaxin (Lucinactant) and The Animal Derived Surfactants Survanta (Beractant) and Curosurf (Poractant Alfa)

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Comparison efficacy of Curosurf and Survanta in preterm infants with respiratory distress syndrome.

Inactivation of pulmonary surfactant due to serum-inhibited adsorption and reversal by hydrophilic polymers: experimental.

Foam film study of albumin inhibited lung surfactant preparations: effect of added hydrophilic polymers

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