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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Moulton, C. M. Hicks, Matthew R. Revilla-López, Guillermo Hamley, I. W. Cheng, G. Rodger, Alison López-Pérez, Daniel E. Alemán, Carlos Castelletto, V. |
| Copyright Year | 2011 |
| Abstract | Self-assembly in aqueous solution has been investigated for two Fmoc [Fmoc = N-(fluorenyl)-9-methoxycarbonyl] tetrapeptides comprising the RGDS cell adhesion motif from fibronectin or the scrambled sequence GRDS. The hydrophobic Fmoc unit confers amphiphilicity on the molecules, and introduces aromatic stacking interactions. Circular dichroism and FTIR spectroscopy show that the self-assembly of both peptides at low concentration is dominated by interactions among Fmoc units, although Fmoc-GRDS shows β-sheet features, at lower concentration than Fmoc-RGDS. Fibre X-ray diffraction indicates β-sheet formation by both peptides at sufficiently high concentration. Strong alignment effects are revealed by linear dichroism experiments for Fmoc-GRDS. Cryo-TEM and small-angle X-ray scattering (SAXS) reveal that both samples form fibrils with a diameter of approximately 10 nm. Both Fmoc-tetrapeptides form self-supporting hydrogels at sufficiently high concentration. Dynamic shear rheometry enabled measurements of the moduli for the Fmoc-GRDS hydrogel, however syneresis was observed for the Fmoc-RGDS hydrogel which was significantly less stable to shear. Molecular dynamics computer simulations were carried out considering parallel and antiparallel β-sheet configurations of systems containing 7 and 21 molecules of Fmoc-RGDS or Fmoc-GRDS, the results being analyzed in terms of both intermolecular structural parameters and energy contributions. |
| Starting Page | 11405 |
| Ending Page | 11415 |
| Page Count | 11 |
| File Format | HTM / HTML PDF |
| ISSN | 1744683X |
| Volume Number | 7 |
| Issue Number | 24 |
| Journal | Soft Matter |
| DOI | 10.1039/c1sm06550e |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Spectroscopy Molecular dynamics Hydrophobe Fibronectin Fluorenylmethyloxycarbonyl protecting group Circular dichroism Small-angle X-ray scattering Gel X-ray crystallography Syneresis (chemistry) Self-assembly Linear dichroism FTIR Cell adhesion Fmoc Beta sheet |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Condensed Matter Physics |
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