NDLI: Electroanalytical determination of diazepam in tablet and human serum samples using a multiwalled carbon nanotube embedded molecularly imprinted polymer-modified carbon paste electrode

Content Provider	Royal Society of Chemistry (RSC)
Author	Motaharian, Ali Hosseini, Mohammad Reza Milani
Copyright Year	2015
Abstract	In this study molecularly imprinted polymers were grafted on the surface of functionalized multiwalled carbon nanotubes (MWCNTs) using diazepam as template molecules. The MWCNTs–MIP were characterized by Fourier transform-infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) and then used for modification of a carbon paste electrode (CPE). Cyclic voltammetry (CV) and square wave voltammetry (SWV) methods were applied to study the binding event and electrochemical behavior of diazepam at the modified carbon paste electrodes. The diazepam binding experiments indicated that the sensor modified by MWCNTs–MIP has much higher adsorption ability than the MWCNTs based non-imprinted polymer (MWCNTs–NIP). Under optimized extraction and analysis conditions, the sensor modified by MWCNTs–MIP exhibited excellent sensitivity (4.0 × 107 μA L mol−1) for diazepam with a linear range of 8.0 × 10−9 to 1.0 × 10−6 mol L−1 (R2 = 0.9972) and detection limit of 3.7 × 10−9 mol L−1. The sensor was successfully applied for determination of diazepam in tablets and human serum samples with recovery values in the range of 91.7–100.2%.
Starting Page	81650
Ending Page	81659
Page Count	10
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	5
Issue Number	99
Journal	RSC Advances
DOI	10.1039/c5ra11598a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Spectroscopy Voltammetry Polymer Fourier-transform infrared spectroscopy Carbon paste electrode Scanning electron microscope Carbon Carbon nanotube Cyclic voltammetry SWV Fourier Adsorption Electrochemistry Diazepam Square wave
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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