NDLI: Layer-by-layer polyelectrolyte complex coated poly(methacrylic acid) nanogels as a drug delivery system for controlled release: structural effects

Content Provider	Royal Society of Chemistry (RSC)
Author	Liu, Peng Li, Xiaorui Du, Pengcheng
Copyright Year	2014
Abstract	Core–shell microspheres have attracted intense interest as drug delivery system (DDS) because of their integrated advantages of the core and shell materials. Here the structural effects, such as the crosslinking degree of the cores and the thickness of the polyelectrolyte complex shells, on the dipyridamole (DIP) loading and release performance were investigated in detail for the first time with the core–shell poly(methacrylic acid)@(chitosan/alginate)n microsphere as a drug carrier model, fabricated by encapsulating poly(methacrylic acid) (PMAA) nanogels in the layer-by-layer (LbL) engineered chitosan/alginate (CS/AL) multilayer shells. The core–shell microspheres with two-bilayer chitosan/alginate shells (PMAA@(CS/AL)2) were selected for the in vitro controlled release of the water-insoluble anticancer drug (doxorubicin (DOX)) in simulated body fluids (SBF). After the encapsulation, the DOX-loading capacity increased from 32.18% to 40.12% and the effect of the media pH values on the cumulative release from the PMAA@(CS/AL)2 was more remarkable than the core material, indicating the encapsulation with the polyelectrolyte multilayer shells was favorable for the drug loading and pH-responsive controlled release. Furthermore, the polyelectrolyte multilayer shells also improved the cytocompatibility of the drug carriers. This understanding will lead to better design of smart core–shell DDS for controlled release.
Starting Page	56323
Ending Page	56331
Page Count	9
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	4
Issue Number	99
Journal	RSC Advances
DOI	10.1039/c4ra05066e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Polyelectrolyte Carboxylic acid Poly(methacrylic acid) Alginic acid Dipyridamole Microparticle Drug delivery Chitosan Doxorubicin
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Zinc Oxide-Incorporated Chitosan-Poly(methacrylic Acid) Polyelectrolyte Complex as a Wound Healing Material.

Gene delivery using dendrimer/pDNA complexes immobilized in electrospun fibers using the Layer-by-Layer technique

A NOVEL METHOD FOR THE PREPARATION OF CONTROLLED-RELEASE THEOPHYLLINE CAPSULES COATED WITH A POLYELECTROLYTE COMPLEX OF K-CARRAGEENAN AND CHITOSAN

Bioresponsive Materials for Drug Delivery Based on Carboxymethyl Chitosan/Poly(γ-Glutamic Acid) Composite Microparticles

Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems

Studies On Preparation Of Poly(Vinyl Pyrrolidone) And Poly (Methacrylic Acid) Microcaopsules For Drug Delivery

Preparation and in vitro drug delivery response of doxorubicin loaded PAA coated magnetite nanoparticles

Methacrylic acid_based functional nanogels as supports for enzyme immobilization and drug delivery devices

Doxorubicin-loaded poly (lactic-co-glycolic acid) nanoparticles coated with chitosan/alginate by layer by layer technology for antitumor applications

Layer-by-layer polyelectrolyte complex coated poly(methacrylic acid) nanogels as a drug delivery system for controlled release: structural effects

Similar Documents

Zinc Oxide-Incorporated Chitosan-Poly(methacrylic Acid) Polyelectrolyte Complex as a Wound Healing Material.

Gene delivery using dendrimer/pDNA complexes immobilized in electrospun fibers using the Layer-by-Layer technique

A NOVEL METHOD FOR THE PREPARATION OF CONTROLLED-RELEASE THEOPHYLLINE CAPSULES COATED WITH A POLYELECTROLYTE COMPLEX OF K-CARRAGEENAN AND CHITOSAN

Bioresponsive Materials for Drug Delivery Based on Carboxymethyl Chitosan/Poly(γ-Glutamic Acid) Composite Microparticles

Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems

Studies On Preparation Of Poly(Vinyl Pyrrolidone) And Poly (Methacrylic Acid) Microcaopsules For Drug Delivery

Preparation and in vitro drug delivery response of doxorubicin loaded PAA coated magnetite nanoparticles

Methacrylic acid_based functional nanogels as supports for enzyme immobilization and drug delivery devices

Doxorubicin-loaded poly (lactic-co-glycolic acid) nanoparticles coated with chitosan/alginate by layer by layer technology for antitumor applications

Layer-by-layer polyelectrolyte complex coated poly(methacrylic acid) nanogels as a drug delivery system for controlled release: structural effects