NDLI: Ammonium chloride mediated synthesis of alkyl glycosides and evaluation of their immunomodulatory activity

Content Provider	Royal Society of Chemistry (RSC)
Author	Yousuf, Syed Khalid Tripathi, Anil K. Mukherjee, Debaraj Sidiq, Tabasum Sharma, Deepak K. Khajuria, Anamika Lambu, Mallikharjuna R.
Copyright Year	2013
Abstract	Therapeutic immunoadjuvants have been derived through a straightforward glycosylation of various alcohols with unprotected and non-activated monosaccharides, under solvent free conditions using ammonium chloride as a catalyst. Sugar acids such as glucuronic acid can be glycosylated without esterification and after acetylation yielded a novel 3,6-anhydro derivative. All the synthesized sugar glycosides were screened for immunomodulatory activities to be classified as immunostimulator, immunosuppressor, or immunoadjuvant against the weak antigen oval albumin (OVA). Most of the compounds revealed immunosuppressive (↓) or immunostimulatory (↑) activity with reference to lymphocyte proliferation and possess potential as vaccine adjuvants.
Starting Page	11450
Ending Page	11455
Page Count	6
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	3
Issue Number	29
Journal	RSC Advances
DOI	10.1039/c3ra41050a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Immunologic adjuvant Albumin Glycosylation Original video animation Vaccine Ammonium chloride Antigen Ester Immunostimulant Immunosuppression Carboxylic acid Carbohydrate Acetylation Solvent
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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Ammonium chloride mediated synthesis of alkyl glycosides and evaluation of their immunomodulatory activity