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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Moore, Thomas Alexis, Frank Podila, Ramakrishna Rao, Apparao M. |
| Copyright Year | 2013 |
| Abstract | In this study, we used graphene, a one-atom thick sheet of carbon atoms, to modify the surfaces of existing implant materials to enhance both bio- and hemo-compatibility. This novel effort meets all functional criteria for a biomedical implant coating as it is chemically inert, atomically smooth and highly durable, with the potential for greatly enhancing the effectiveness of such implants. Specifically, graphene coatings on nitinol, a widely used implant and stent material, showed that graphene coated nitinol (Gr–NiTi) supports excellent smooth muscle and endothelial cell growth leading to better cell proliferation. The authors further determined that the serum albumin adsorption on Gr–NiTi is greater than that of fibrinogen, which is an important and well understood criterion for promoting a lower thrombosis rate. These hemo- and biocompatible properties, along with high strength, chemical inertness and durability provide graphene with an edge over most antithrombogenic coatings for biomedical implants and devices. |
| Starting Page | 1660 |
| Ending Page | 1665 |
| Page Count | 6 |
| File Format | HTM / HTML PDF |
| ISSN | 20462069 |
| Volume Number | 3 |
| Issue Number | 6 |
| Journal | RSC Advances |
| DOI | 10.1039/c2ra23073a |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Adsorption Graphene Fibrinogen Smooth muscle tissue Biocompatibility Serum albumin Carbon Stent Thrombosis Endothelium |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Chemical Engineering |
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