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Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ogihara, Nobuhide Usui, Yuki Aoki, Kozaburo Shimizu, Michihiro Narita, Nobuyo Hara, Kousuke Nakamura, Koichi Ishigaki, Norio Takanashi, Seiji Okamoto, Masanori Namiki Kato, Hiroyuki Haniu, Hisao Ogiwara, Naoko Nakayama, Noboru Taruta, Seiichi Saito, Naoto |
| Copyright Year | 2012 |
| Abstract | AIMS The addition of carbon nanotubes (CNTs) remarkably improves the mechanical characteristics of base materials. CNT/alumina ceramic composites are expected to be highly functional biomaterials useful in a variety of medical fields. Biocompatibility and bone tissue compatibility were studied for the application of CNT/alumina composites as biomaterials. METHODS & RESULTS Inflammation reactions in response to the composite were as mild as those of alumina ceramic alone in a subcutaneous implantation study. In bone implantation testing, the composite showed good bone tissue compatibility and connected directly to new bone. An in vitro cell attachment test was performed for osteoblasts, chondrocytes, fibroblasts and smooth muscle cells, and CNT/alumina composite showed cell attachment similar to that of alumina ceramic. DISCUSSION & CONCLUSION Owing to proven good biocompatibility and bone tissue compatibility, the application of CNT/alumina composites as biomaterials that contact bone, such as prostheses in arthroplasty and devices for bone repair, are expected. |
| Starting Page | 291 |
| Ending Page | 293 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://soar-ir.repo.nii.ac.jp/index.php?action=pages_view_main&active_action=repository_action_common_download&attribute_id=65&block_id=45&file_no=1&item_id=7199&item_no=1&page_id=13 |
| PubMed reference number | 22401267v1 |
| Alternate Webpage(s) | https://doi.org/10.2217/nnm.12.1 |
| DOI | 10.2217/nnm.12.1 |
| Journal | Nanomedicine |
| Volume Number | 7 |
| Issue Number | 7 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aluminum Oxide Arthroplasty Biomaterials Bone Tissue Cell-Matrix Junction Ceramics Chondrocyte Medical Device Incompatibility Problem Nanotubes Nanotubes, Carbon Osteoblasts Prosthesis Smooth muscle (tissue) biocompatibility |
| Content Type | Text |
| Resource Type | Article |
