NDLI: A macrocyclic oligoelectrolyte as a facial platform for absorbing hyaluronic acid oligomers for targeted cancer cellular imaging

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Polymer Chemistry Vol - 6 Issue - 19

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Polymer Chemistry Vol -1

A macrocyclic oligoelectrolyte as a facial platform for absorbing hyaluronic acid oligomers for targeted cancer cellular imaging

Content Provider	Royal Society of Chemistry (RSC)
Author	Song, Wenli Deng, Weixing Hu, Wenbo Quan, Yiwu Tian, Congcong Li, Jie Huang, Wei Jiang, Rongcui Sun, Pengfei Fan, Quli Yin, Chao Lu, Xiaomei
Copyright Year	2015
Abstract	A novel water-soluble macrocyclic oligoelectrolyte (MOE) was designed and synthesized by a simple Friedel–Crafts reaction as a facial platform for fabricating biological nanoparticles. The produced MOE with a unique three-dimension (3D) rigid structure consisted of a triphenylamine-based cyclic core and three oligofluorene arms, which protruded from the ring plane on both sides. The specific structure rendered MOE with good photoluminescence (PL) stabilities, low aggregation tendencies and excellent water-soluble properties in the form of well-defined smart organic dots (sub-10 nm) in aqueous solution. Using these organic dots as a template and OHAs, a biocompatible and linear oligosaccharide made straightforward contact with CD44 (a principal cell surface receptor for HA). As a stabilizer and biomarker, functional nanoparticles (MHNs-0.4) were fabricated via electronic interaction induced self-assembly in aqueous solution. The final confirmed MHNs-0.4 with suitable size (around 80 nm), good stability and fluorescent properties were found to be outstanding materials for the specific labelling of CD44-overexpressed human lung cancer cells (A549). The highlight of the study is that we provided a powerful and reliable platform, MOE-dots, for adsorbing various negatively charged molecules and broadening potential biological applications.
Starting Page	5295
Ending Page	5304
Page Count	10
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	6
Issue Number	29
Journal	Polymer Chemistry
DOI	10.1039/c5py00633c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Friedel MOE Biomarker Self-assembly Cell surface receptor Oligosaccharide Lung cancer Photoluminescence Friedel\u2013Crafts reaction Biocompatibility CD44 Three-dimensional space
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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