NDLI: Versatile injectable supramolecular hydrogels containing drug loaded micelles for delivery of various drugs

Content Provider	Royal Society of Chemistry (RSC)
Author	Yao, Ping Liu, Zhijia
Copyright Year	2014
Abstract	In this study, a novel glycol chitosan-Pluronic F127 conjugate (GC-PF127) was produced by adding a carboxyl group to the end of Pluronic F127 followed by an amidation reaction between carboxylated Pluronic F127 and glycol chitosan. Because of the hydrophobic aggregation of PPO segments in Pluronic F127, GC-PF127 self-assembles into micelles in aqueous solution at room temperature. The micelles can effectively load amphiphilic doxorubicin (DOX) and partly load negatively charged protein superoxide dismutase (SOD) at neutral pH with different mechanisms, but cannot load hydrophilic 5-fluorouracil (5-FU). The respective DOX/GC-PF127, SOD/GC-PF127, and 5-FU/GC-PF127 micelle solutions can be converted to injectable supramolecular hydrogels by addition of α-CD. The strength and dissociation rate of the hydrogels can be tuned by the α-CD concentration. The hydrogel structure can recover immediately after extrusion of the hydrogel using a syringe. The hydrogels have prolonged and almost linear release behaviours for various drugs. The hydrogels release free drugs as well as drug loaded micelles via the dissociation of the hydrogels under physiological conditions, which may enhance the targeting ability and therapeutic efficiency. The released micelles sequentially release free drugs that further prolong the release of the drugs. GC-PF127 hydrogels are versatile injectable hydrogels which can deliver various drugs.
Starting Page	1072
Ending Page	1081
Page Count	10
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	5
Issue Number	3
Journal	Polymer Chemistry
DOI	10.1039/c3py01083j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Micelle Superoxide dismutase Hydrophobe Dissociative Doxorubicin Protein Gel Carboxylic acid Amide Amphiphile Chitosan Hydrophile Fluorouracil
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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