NDLI: An injectable hyaluronic acid/PEG hydrogel for cartilage tissue engineering formed by integrating enzymatic crosslinking and Diels

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An injectable hyaluronic acid/PEG hydrogel for cartilage tissue engineering formed by integrating enzymatic crosslinking and Diels–Alder “click chemistry”

Back cover

Polymer Chemistry Vol -4

Polymer Chemistry Vol -3

Polymer Chemistry Vol -2

Polymer Chemistry Vol -1

An injectable hyaluronic acid/PEG hydrogel for cartilage tissue engineering formed by integrating enzymatic crosslinking and Diels–Alder “click chemistry”

Content Provider	Royal Society of Chemistry (RSC)
Author	Cao, Xiaodong Li, Yuli Yuan, Bo Yu, Feng Zeng, Lei Chen, Xiaofeng
Copyright Year	2014
Abstract	The application of enzymatic crosslinking and Diels–Alder (DA) click chemistry for hydrogel formation has recently bloomed, because of the efficient chemical bonding and the mild biological reaction conditions. In this study, an injectable hyaluronic acid/PEG (HA/PEG) hydrogel was successfully fabricated for the first time through integrating two cross-linking processes, including firstly enzymatic crosslinking and subsequent DA click chemistry. The enzymatic crosslinking resulted in a fast gelation of HA/PEG in 5 min, leading to the formation of an injectable material. In addition, the DA click reaction crosslinking made a hydrogel that has outstanding shape memory and anti-fatigue properties. The storage modulus and breakage strength of the hydrogels were close to 27 kPa and 109.4 kPa, respectively. The compressive strain could reach up to 81.9%. After 10 cycles of a loading and unloading test, the hydrogel still could be loaded by 80 kPa for 1 min and the corresponding deformation could be completely recovered in 1 min after unloading. The ATDC-5 cells were capsulated into the hydrogel bulk in situ and showed high metabolic viability and proliferation. All of these results suggest that the HA/PEG injectable hydrogel formed by integrating the two cross-linking processes has a great potential in cartilage tissue engineering.
Starting Page	1082
Ending Page	1090
Page Count	9
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	5
Issue Number	3
Journal	Polymer Chemistry
DOI	10.1039/c3py00869j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Cartilage Tissue engineering Click chemistry Diels\u2013Alder reaction Shape-memory alloy Pascal (unit) Gel
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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