NDLI: Highly bioavailable anticancer herbal-loaded nanocarriers for use against breast and colon cancer in vitro and in vivo systems

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Highly bioavailable anticancer herbal-loaded nanocarriers for use against breast and colon cancer in vitro and in vivo systems

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Back cover

Polymer Chemistry Vol - 4 Issue - 5

Polymer Chemistry Vol - 4 Issue - 4

Polymer Chemistry Vol - 4 Issue - 3

Polymer Chemistry Vol -3

Polymer Chemistry Vol -2

Polymer Chemistry Vol -1

Highly bioavailable anticancer herbal-loaded nanocarriers for use against breast and colon cancer in vitro and in vivo systems

Content Provider	Royal Society of Chemistry (RSC)
Author	Chou, Chih-Wei Lin, Hong-Ru Chung, Jing-Gun Hung, Huey-Shan Kuo, Yueh-Hsiung Batnyam, Onon Shih, Yang-Chia Lee, Wen-Fu Yen, Ssu-Yin Tsao, Min-Han Harn, Horng-Jyh
Copyright Year	2013
Abstract	This study focused on designing a large-scale producible vehicle for the pharmaceutically important compound berberine, to simultaneously improve its bioavailability against cancer cells and reduce cytotoxicity toward normal cells. This vehicle is composed of chitosan and tripolyphosphate, and was prepared with a simple ionic cross-linking method. The properties of the berberine-loaded chitosan-tripolyphosphate nanoparticles (BB-LCTNP) were dependent on berberine, chitosan, and tripolyphosphate concentrations. The bioavailability improvement and anticancer efficiency of the BB-LCTNPs were analyzed using MDA-MB-435 and Colo-205 cells. The results revealed that the particle size, loading efficiency, and IC50 of the BB-LCTNPs can be controlled easily. The pharmacodynamic availability of berberine increased up to 3 times when loaded into the nanoparticles because they directly targeted cancer cell nuclei. Moreover, the BB-LCTNPs were non-toxic toward normal cells. In vivo studies revealed that BB-LCTNPs can reduce drug dosages up to 3 times and suppress tumor growth. The surfaces of the prepared BB-LCTNPs were modified using mPEG acid, but the in vitro and in vivo studies of these particles are currently ongoing.
Starting Page	2040
Ending Page	2052
Page Count	13
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	4
Issue Number	6
Journal	Polymer Chemistry
DOI	10.1039/c2py20972a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Berberine Pharmacodynamics Cell nucleus IC50 Cytotoxicity Bioavailability Chitosan Cancer NCI-60
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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Designing nanostructured lipid carriers modified with folate-conjugated chitosan for targeted delivery of osthole to HT-29 colon cancer cells: investigation of anticancer, antioxidant, and antibacterial activities

Highly bioavailable anticancer herbal-loaded nanocarriers for use against breast and colon cancer in vitro and in vivo systems

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