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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Li, Jingchao Shi, Xiangyang Cao, Xueyan Guo, Rui Wang, Jianhua Li, Du Chen, Guangxiang |
| Copyright Year | 2015 |
| Abstract | In this study, we covalently conjugated polyethylene glycol-linked lactobionic acid (PEG-LA) onto the surface of laponite (LAP) nanodisks for the targeted delivery of doxorubicin (DOX) to liver cancer cells. LAP nanodisks were firstly modified with 3-aminopropyldimethylethoxysilane to introduce amino groups on the surface, and then PEG-LA were successfully conjugated to form targeted LM-PEG-LA nanodisks via EDC chemistry. Finally, the anticancer drug DOX was encapsulated into the synthesized nanocarriers with an exceptionally high loading efficiency of 91.5%. In vitro release studies showed that LM-PEG-LA/DOX could release drugs in a sustained manner with a higher speed under acidic conditions than that under physiological ones. MTT assay results proved that LM-PEG-LA/DOX displayed a significant higher therapeutic efficacy in inhibiting the growth of hepatocellular carcinoma cells (HepG2 cells) than untargeted ones at the same DOX concentration. The targeting specificity of LM-PEG-LA/DOX was further demonstrated by flow cytometric analysis and confocal laser scanning microscopy. The developed LA-modified LAP nanodisks could serve as a targeted carrier for efficient loading and specific delivery of different anticancer drugs to liver cancer cells. |
| Starting Page | 2847 |
| Ending Page | 2855 |
| Page Count | 9 |
| File Format | HTM / HTML PDF |
| ISSN | 11440546 |
| Volume Number | 39 |
| Issue Number | 4 |
| Journal | New Journal of Chemistry |
| DOI | 10.1039/c4nj01916d |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Flow cytometry Polyethylene Chemistry Carcinoma EDC Carboxylic acid Hepatocellular carcinoma Confocal microscopy MTT Doxorubicin MTT assay |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Materials Chemistry Catalysis |
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