Please wait, while we are loading the content...
| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Swart, Hendrik C. Kumar, Vijay Pandey, Anurag Kaith, Balbir Singh Kumar, Vinod Sharma, Kashma Som, Sudipta Kalia, Susheel |
| Copyright Year | 2015 |
| Abstract | The objective of the present investigation was to develop colon-specific drug delivery systems for amoxicillin trihydrate and paracetamol using Gum ghatti (Gg) based cross-linked hydrogels. An interpenetrating network (IPN) of electrically active hydrogel based on Gg, poly(acrylic acid) (AA) and polyaniline was synthesized by a two-step aqueous polymerization. The radical copolymerization of Gg and AA was done using N,N′-methylene-bis-acrylamide (MBA) and ammonium persulphate (APS) as a crosslinker-initiator system. Optimum operating conditions for maximizing the percentage swelling were solvent (ml) = 10, AA (mol L−1) = 0.291 × 10−3, APS (mol L−1) = 0.219 × 10−1, MBA (mol L−1) = 0.324 × 10−1, reaction time (min) = 180, temperature (°C) = 60 and pH = 7.0. The synthesized semi-IPN matrix was further grafted with aniline through oxidative-radical copolymerization using APS in acidic media. The resultant cross-linked hydrogels were characterized using X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, ToF-SIMS and electrical conductivity. The maximum conductivity was found to be 2.5 × 10−6 S cm−1 at 1.5 N HCl concentration. The synthesized hydrogels were loaded with amoxicillin trihydrate and paracetamol as model drugs to investigate the release behaviour. Amoxicillin trihydrate follows the surface phenomena and weak bonding interaction whereas paracetamol exhibited chemical interaction with the hydrogel matrices. The release rate of both the drugs through the synthesized hydrogel matrices was found to show Fickian behaviour at each pH. The hydrogel networks showed lower release in acidic and neutral media than in basic media, making them particularly suitable carriers for colon-specific drug delivery. |
| Starting Page | 3021 |
| Ending Page | 3034 |
| Page Count | 14 |
| File Format | HTM / HTML PDF |
| ISSN | 11440546 |
| Volume Number | 39 |
| Issue Number | 4 |
| Journal | New Journal of Chemistry |
| DOI | 10.1039/c4nj01982b |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Infrared spectroscopy Ammonium APS Thermogravimetric analysis IPN Institute of National Remembrance Polymerization Drug delivery Polyaniline Gel X-ray crystallography Electrical resistivity and conductivity Hydrochloric acid Paracetamol Fourier Aniline Amoxicillin PH Extracellular matrix Master of Business Administration Solvent |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Materials Chemistry Catalysis |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|