NDLI: Lipid–polymer hybrid nanoparticles for synergistic drug delivery to overcome cancer drug resistance

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Back cover

New Journal of Chemistry Vol - 41 Issue - 3

New Journal of Chemistry Vol - 41 Issue - 2

New Journal of Chemistry Vol - 41 Issue - 1

New Journal of Chemistry Vol -39

New Journal of Chemistry Vol -29

New Journal of Chemistry Vol -0

Lipid–polymer hybrid nanoparticles for synergistic drug delivery to overcome cancer drug resistance

Content Provider	Royal Society of Chemistry (RSC)
Author	Chen, Yi-Zhen Liu, Hong Zeng, Shao-Qi Chen, Yong
Copyright Year	2017
Abstract	To overcome the major obstacle of successful cancer chemotherapy, multidrug resistance (MDR), we prepared lipid-shell and polymer-core nanoparticles (LPNPs) to co-deliver an anticancer drug and a drug resistance inhibitor to achieve a synergistic effect and to overcome cancer drug resistance. LPNPs are composed of a core of cholic acid functionalized star poly(DL-lactide) with a fast degradation and surface erosion degradation mechanism and a shell of lecithin decorated by DSPE-PEG. A chemotherapeutic drug (paclitaxel, PTX) and a cyclooxygenase-2 inhibitor (celecoxib, CXB) to down-regulate P-gp expression were co-loaded in the lipid–polymer hybrid nanoparticles to obtain PTX/CXB@LPNP. As compared with liposomes without polymer cores, PTX/CXB@LPNP sustains the drug release more efficiently. The in vitro cell inhibition efficiency of the drug loaded nanoparticles was evaluated in drug resistant cells (MCF-7/ADR) and nonresistant cells (HeLa). The results demonstrate that dual-drug loaded PTX/CXB@LPNP exhibits a significantly enhanced cell inhibitory effect as compared with mono-drug loaded PTX@LPNP. Consistently, apoptosis assay by flow cytometry indicates that PTX/CXB@LPNP can induce both early apoptosis and late apoptosis more effectively than PTX@LPNP. The enhanced therapeutic efficiency of PTX/CXB@LPNP is attributed to the down-regulation of P-gp expression mediated by CXB, which results in decreased drug-efflux mediated by P-gp. In addition, PTX/CXB@LPNP results in a significant decrease in cytokine IL-10 produced by the drug resistant tumor cells, implying that the drug delivery system is favorable in reversal of the immunosuppressive environment. The lipid–polymer hybrid nanoparticles have promising applications in synergistic drug delivery to overcome cancer drug resistance.
Starting Page	1518
Ending Page	1525
Page Count	8
File Format	HTM / HTML PDF
ISSN	11440546
Volume Number	41
Issue Number	4
Journal	New Journal of Chemistry
DOI	10.1039/c6nj02819e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Flow cytometry Lecithin MCF-7 Cytokine Enzyme inhibitor Polymer Drug delivery Celecoxib CXB HeLa Chemotherapy Cyclooxygenase Paclitaxel Interleukin 10 Cancer Multiple drug resistance Apoptosis
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Catalysis

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