NDLI: A unique cysteine selective water soluble fluorescent probe operable in multiple sensing cycles for the detection of biogenic cysteine in multicellular living species

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Back cover

New Journal of Chemistry Vol - 41 Issue - 3

New Journal of Chemistry Vol - 41 Issue - 2

New Journal of Chemistry Vol - 41 Issue - 1

New Journal of Chemistry Vol -39

New Journal of Chemistry Vol -29

New Journal of Chemistry Vol -0

A unique cysteine selective water soluble fluorescent probe operable in multiple sensing cycles for the detection of biogenic cysteine in multicellular living species

Content Provider	Royal Society of Chemistry (RSC)
Author	Das, Sanju Majumder, Rini Sarkar, Yeasmin Bandyopadhyay, Jaya Parui, Partha Pratim Mukherjee, Santanu Ray, Ambarish
Copyright Year	2017
Abstract	The Schiff base ligand (L1) showing large fluorescence intensity in an aqueous medium owing to a ground state intramolecular proton transfer (GSIPT) reaction was utilized in a complexation process to generate a highly stable non-fluorescent Cu(II)/L1 (1) in its “turn-off” mode. The 3:2 Cu(II)/L1 stoichiometric complex (1), isolated in the solid form, exhibited a cysteine (Cys)-induced “turn-on” fluorescence response with a unique time-dependent intensity variation. Unlike other biothiols, the partially deprotonated –SH moiety in Cys is highly susceptible for participating in an ionic interaction with Cu(II)-centres in 1 at a physiological pH of ∼7.4, followed by reduction to Cu(I), and then a subsequent demetallation, resulting in a large increment of the fluorescence intensity for free fluorophoric L1, which persists for about 4 –13 min owing to an unexpected stability of the Cu(I) ions. After Cys consumption, Cu(I) ions in aqueous solution rapidly oxidize to participate further in complexation with the existing free L1. The resulting complex may again be susceptible to Cys-induced abovementioned decomplexation followed by complexation for at least four different external Cys additions in four successive cyclic pathways. This multiple Cys sensing behaviour has been exploited to recognize the existence of Cys in multicellular Caenorhabditis elegans (C. elegans).
Starting Page	1488
Ending Page	1498
Page Count	11
File Format	HTM / HTML PDF
ISSN	11440546
Volume Number	41
Issue Number	4
Journal	New Journal of Chemistry
DOI	10.1039/c6nj03291e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Schiff base Stoichiometry Cysteine Staurogyne elegans Ligand Schiff Fluorescence Proton PH
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Catalysis

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