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| Content Provider | Springer Nature Link |
|---|---|
| Author | Liu, Bo Ya Wu, Cong He, Xiao Yan Zhuo, Ren Xi Cheng, Si Xue |
| Copyright Year | 2016 |
| Abstract | A facile self-assembly strategy to fabricate vitamin E-tocopheryl polyethylene glycol succinate (TPGS) based nanoparticles with a high drug loading level for co-delivery of multiple drugs was developed. To overcome multi-drug resistance, a chemotherapeutic agent (paclitaxel, PTX) and a drug resistance inhibitor (tariquidar, TQR) were co-loaded in the vitamin E-TPGS based nanoparticle to obtain TPGS/PTX/TQR nanoparticles. The sizes of mono-drug loaded TPGS/PTX nanoparticles and dual-drug loaded TPGS/PTX/TQR nanoparticles were below 150 nm with relatively narrow size distributions. The efficiencies of the drug delivery systems on tumor cells inhibition and reversal of drug resistance were evaluated in drug resistant cancer cells (MCF-7/ADR) as compared with nonresistant cells (HeLa). Due to the effective inhibition of the P-gp efflux by TQR, the dual-drug loaded nanoparticles exhibited significantly improved tumor cell inhibitory efficiency. To study the immunostimulatory effect, the effect of the drug delivery system on the production of IL-10, a cytokine related to tumor development, in the drug resistant cells was determined. After the treatment by the drug delivery systems, the concentration of IL-10 in the cell supernatant decreased. The multi-drug loaded vitamin E-TPGS nanoparticles for synergistic drug delivery have promising applications in reversal of drug resistance in tumor treatments.为了克服肿瘤的多药耐药性,本研究通过自组装制备了一种同时负载化疗药物和耐药抑制剂的维生素E-TPGS纳米粒子。通过耐药抑制剂抑制P糖蛋白,防止耐药细胞将抗癌药物排出细胞外,协同载药纳米粒子能够有效抑制耐药肿瘤细胞的生长。此外,还检测了载药纳米粒子处理后,耐药肿瘤细胞的免疫相关因子IL-10的表达,为药物传递系统对肿瘤免疫的影响提供了依据。 |
| Starting Page | 552 |
| Ending Page | 560 |
| Page Count | 9 |
| File Format | |
| ISSN | 20959273 |
| Journal | Chinese Science Bulletin |
| Volume Number | 61 |
| Issue Number | 7 |
| e-ISSN | 20959281 |
| Language | English |
| Publisher | Science China Press |
| Publisher Date | 2016-03-14 |
| Publisher Place | Beijing |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Multi-drug resistance Drug delivery Paclitaxel Tariquidar TPGS Science Life Sciences Physics Chemistry/Food Science Earth Sciences Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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