NDLI: PEG-templated mesoporous silica nanoparticles exclusively target cancer cells

Content Provider	Royal Society of Chemistry (RSC)
Author	Sisci, Diego Andò, Sebastiano Versace, Carlo Pasqua, Luigi Maris, Pamela Casula, Maria Francesca Panno, Maria Luisa Testa, Flaviano Tagarelli, Antonio Brunelli, Elvira Perrotta, Ida Morelli, Catia Perrotta, Enrico Nagy, Janos B.
Copyright Year	2011
Abstract	Mesoporous silica nanoparticles (MSNs) have been proposed as DNA and drug delivery carriers, as well as efficient tools for fluorescent cell tracking. The major limitation is that MSNs enter cells regardless of a target-specific functionalization. Here we show that non functionalized MSNs, synthesized using a PEG surfactant-based interfacial synthesis procedure, do not enter cells, while a highly specific, receptor mediated, cellular internalization of folic acid (FOL) grafted MSNs (MSN-FOL), occurs exclusively in folate receptor (FR) expressing cells. Neither the classical clathrin pathway nor macropinocytosis is involved in the MSN endocytic process, while fluorescent MSNs (MSN-FITC) enter cells through aspecific, caveolae-mediated, endocytosis. Moreover, internalized particles seem to be mostly exocytosed from cells within 96 h. Finally, cisplatin (Cp) loaded MSN-FOL were tested on cancerous FR-positive (HeLa) or normal FR-negative (HEK293) cells. A strong growth arrest was observed only in HeLa cells treated with MSN-FOL-Cp. The results presented here show that our mesoporous nanoparticles do not enter cells unless opportunely functionalized, suggesting that they could represent a promising vehicle for drug targeting applications.
Starting Page	3198
Ending Page	3207
Page Count	10
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	3
Issue Number	8
Journal	Nanoscale
DOI	10.1039/c1nr10253b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Clathrin Cell surface receptor MSN Pinocytosis Drug delivery Cisplatin HeLa Mesoporous material Endocytosis Classical mechanics Mesoporous silica DNA Interfacial polymerization Folate receptor
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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