NDLI: Potato virus X, a filamentous plant viral nanoparticle for doxorubicin delivery in cancer therapy

Content Provider	Royal Society of Chemistry (RSC)
Author	Steinmetz, Nicole F. Commandeur, Ulrich Shukla, Sourabh Le, Duc H. T. Lee, Karin L.
Copyright Year	2017
Abstract	Plant viral nanoparticles (VNPs) are a novel class of nanocarriers with implications for drug delivery in cancer therapy. VNPs are characterized by their highly symmetrical nanoscale structures. Furthermore, plant VNPs are biocompatible, biodegradable, and non-infectious in mammals. VNPs provide a proteinaceous platform technology that can be readily engineered to carry contrast agents and therapies using chemical and genetic modifications. Of particular interest are high aspect ratio, elongated filaments such as the ones formed by potato virus X (PVX, measuring 515 × 13 nm). PVX has demonstrated enhanced tumor homing and penetration properties compared to spherical counterparts. Here, we sought to investigate the potential of PVX as a drug carrier delivering doxorubicin (DOX), a commonly used cancer chemotherapy. We synthesized therapeutic PVX nanoparticles using a simple in-solution mixing protocol; after 5 days of mixing of DOX and PVX and ultra-centrifugal purification, ∼1000 DOX per PVX were stably associated with the carrier, most likely based on hydrophobic interaction. Efficacy and drug activity of PVX–DOX were confirmed using a panel of cancer cell lines including ovarian cancer, breast cancer, and cervical cancer. Lastly, we demonstrated treatment of athymic mice bearing human MDA-MB-231 breast cancer xenografts: PVX–DOX treatment resulted in reduced tumor growth in this model. Our results open the door for further development of PVX and other high aspect ratio plant VNPs for applications in cancer therapy.
Starting Page	2348
Ending Page	2357
Page Count	10
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	9
Issue Number	6
Journal	Nanoscale
DOI	10.1039/c6nr09099k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Biodegradation Drug delivery Breast cancer Hydrophobe Doxorubicin Ovarian cancer Chemotherapy Potato virus X Biocompatibility List of breast cancer cell lines Photolithography Cervical cancer Cancer
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

PEGylated hyperbranched polyphosphoester based nanocarriers for redox-responsive delivery of doxorubicin

Zirconium phosphate nanoplatelets: a biocompatible nanomaterial for drug delivery to cancer

Increased Tumor Homing and Tissue Penetration of the Filamentous Plant Viral Nanoparticle Potato virus X

Phase-change material filled hollow magnetic nanoparticles for cancer therapy and dual modal bioimaging

Dependence of gold nanoparticle radiosensitization on cell geometry

Nanoparticle-Based Combination Therapy for Ovarian Cancer.

Lipid-enveloped hybrid nanoparticles for drug delivery

The development of low-molecular weight hydrogels for applications in cancer therapy

Nanoparticle hardness controls the internalization pathway for drug delivery

Potato virus X, a filamentous plant viral nanoparticle for doxorubicin delivery in cancer therapy

Similar Documents

PEGylated hyperbranched polyphosphoester based nanocarriers for redox-responsive delivery of doxorubicin

Zirconium phosphate nanoplatelets: a biocompatible nanomaterial for drug delivery to cancer

Increased Tumor Homing and Tissue Penetration of the Filamentous Plant Viral Nanoparticle Potato virus X

Phase-change material filled hollow magnetic nanoparticles for cancer therapy and dual modal bioimaging

Dependence of gold nanoparticle radiosensitization on cell geometry

Nanoparticle-Based Combination Therapy for Ovarian Cancer.

Lipid-enveloped hybrid nanoparticles for drug delivery

The development of low-molecular weight hydrogels for applications in cancer therapy

Nanoparticle hardness controls the internalization pathway for drug delivery

Potato virus X, a filamentous plant viral nanoparticle for doxorubicin delivery in cancer therapy