NDLI: Phosphocholine-decorated superparamagnetic iron oxide nanoparticles: defining the structure and probing in vivo applications

Content Provider	Royal Society of Chemistry (RSC)
Author	Paduano, Luigi Menichetti, Luca Irace, Carlo Heenan, Richard K. Santamaria, Rita Luchini, Alessandra Montesarchio, Daniela Szekely, Noemi Flori, Alessandra
Copyright Year	2016
Abstract	Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are performing contrast agents for Magnetic Resonance Imaging (MRI). A functionalization strategy for SPIONs based on hydrophobic interactions is a versatile approach easily extendable to several kinds of inorganic nanoparticles and suitable for obtaining stable and biocompatible systems. Here we report on the original preparation of functionalized SPIONs with an 8 nm radius exploiting the hydrophobic interaction between a phosphocholine and an inner amphiphilic. With respect to other similarly functionalized SPIONs, characterized by the typical nanoparticle clustering that leads to large aggregates, our phosphocholine-decorated SPIONs are demonstrated to be monodisperse. We report the in vitro and in vivo study that proves the effective applicability of phosphocholine-decorated SPIONs as MRI contrast agents. The versatility of this functionalization approach is highlighted by introducing on the SPION surface a ruthenium-based potential antitumoral drug, named ToThyCholRu. Even if in this case we observed the formation of SPION clusters, ascribable to the presence of the amphiphilic ruthenium complex, interesting and promising antiproliferative activity points at the ToThyCholRu-decorated SPIONs as potential theranostic agents.
Starting Page	10078
Ending Page	10086
Page Count	9
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	8
Issue Number	19
Journal	Nanoscale
DOI	10.1039/c5nr08486e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Dispersity Ruthenium Magnetic resonance imaging Nanoparticle Biocompatibility Amphiphile Hydrophobe Phosphocholine
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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Electronic Supplementary Information Phosphocholine-decorated Superparamagnetic Iron Oxide Nanoparticles: Defining the Structure and Probing in Vivo Application. Small Angle X-ray Scattering (saxs)

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Correction: Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents

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Phosphocholine-decorated superparamagnetic iron oxide nanoparticles: defining the structure and probing in vivo applications

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Electronic Supplementary Information Phosphocholine-decorated Superparamagnetic Iron Oxide Nanoparticles: Defining the Structure and Probing in Vivo Application. Small Angle X-ray Scattering (saxs)

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Phosphocholine-decorated superparamagnetic iron oxide nanoparticles: defining the structure and probing in vivo applications